Principal Scientist Metabolism Bioscience Research, CVRM

Principal Scientist Metabolism Bioscience Research, CVRM US - Gaithersburg - MD Apr 24, 2026

$173K - $259K

Job Title: Principal Scientist (Director level), Metabolism Bioscience Research Location: Gaithersburg, MD (US) We are seeking a passionate and accomplished Principal Scientist with expertise in skeletal muscle physiology, metabolism, and drug discovery to join our vibrant research community in the Metabolism Bioscience Division within Early CVRM Research and Development. The Metabolism Bioscience Division is one of the three main therapeutic research areas within the Bioscience department that delivers candidate drugs into clinical development. The Early CVRM Bioscience department provides a dynamic environment that fosters collaboration and innovation, advancing science to discover novel therapeutics for patients with obesity, diabetes, and associated comorbidities. Responsibilities Apply expertise in skeletal muscle physiology and metabolic diseases to drive scientific and technical innovation, identify and advance new therapeutic interventions. Lead multidisciplinary global project teams and external collaborations to deliver key experimental data and progress the drug project portfolio. Champion novel approaches to drug discovery for healthy body weight loss and maintenance, facilitating scientific debate and innovation through leadership and mentorship within the CVRM Research community. Contribute to the evolution of research strategy within the Metabolism Bioscience division as a member of its leadership team. Play a lead role in the selection and validation of research targets, leading projects from discovery through to early clinical development, and serve as Bioscience lead on drug discovery projects. Raise the scientific profile of Early CVRM internally and externally through high-impact publications, conference presentations, and leading collaborative initiatives. Qualifications PhD in a relevant scientific discipline (e.g., metabolic diseases, musculoskeletal diseases, neuroscience, immunology). 5+ years’ drug discovery or relevant experience in academia, biotech, or pharmaceutical industry following postdoctoral research. Deep expertise in skeletal muscle biology and physiology, including in vitro, ex vivo, and in vivo assay development. Extensive scientific knowledge of metabolic diseases and mechanisms of body weight regulation, alongside a strong track record of leading laboratory-based research. Experience in new model development, laboratory techniques, and enthusiasm for performing hands‑on science. Demonstrated scientific leadership reflected by a robust publication track record in high‑impact journals, external presentations, and collaborations. Proven ability to manage multifaceted projects and establish research collaborations, leveraging a broad professional network. Track record as a project leader or bioscience lead, conducting, planning, and guiding complex scientific projects within multidisciplinary teams. Significant experience with in vitro, in vivo, and ex vivo technologies to assess multiple target classes. Ability to manage multiple concurrent projects or tasks. Extensive network and collaboration experience within the metabolic diseases research field. The annual base pay for this position ranges from $172,672.00 to $259,008.00 USD annually. In addition to base salary, the position offers eligibility for short‑term incentive bonuses, equity‑based awards for salaried roles, and commissions for sales roles. Benefits include qualified retirement programs, paid time off, and health, dental, and vision coverage in accordance with applicable plans. Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. #J-18808-Ljbffr Dormont Manufacturing Co