SeniorResearch Associate, Chemistry R&D

Company Overview Sarmal, Inc. is a San Diego–based biotechnology company developing next-generation genomics and molecular detection platforms. Our work integrates molecular biology, chemistry, and advanced systems engineering to enable faster, more precise, and more accessible genomic insights. We are a highly collaborative, R&D-driven teamoperatingin a fast-paced, early-stage environment. Our scientists and engineers work across disciplines to solve complex technical challenges and translate innovation into scalable, real-world applications. AtSarmal, we value scientific rigor, curiosity, and a buildermindset. We are looking for individuals who are energized by ambiguity, motivated by impact, and excited to help bring breakthrough technologies from concept to reality. About the Job TheChemistry R&DSeniorResearch Associatewillexecutethesynthesis, purification, characterization, and QC analysis of novel modified nucleoside/nucleotide motifs that are needed for broader R&D efforts within the organization. This rolerequires hands-on experience in an industrial organic chemistry lab setting, and the chemist should be comfortable working with sensitive compounds and complex purification and QC analysis techniques.This chemist will contribute todevelopmentof crucial upstream materials that will pillar the core technology atSarmal. Key Responsibilities Synthesizemodifiednucleosides/nucleotides usinga variety ofsynthesis techniques. Purify reaction products using preparative HPLC, flash chromatography, and otherappropriate purificationmethods. Characterizecompoundsusing analyticaltechniques includingLC-MS, NMR, IR, UV/Vis, TLC, and related methods. Optimizereaction conditions anddevelopanalytical methodsto produce high-qualitycompoundsthat meet project requirements. Maintainaccurateand detailed electronic laboratory notebooks and manage inventory of synthesized compounds and related materials. Operate,maintain, and troubleshoot laboratory equipment and analytical instrumentation. Analyze and interpret experimental data and present findings at project and departmental meetings. Qualifications Strongunderstanding of modern organic chemistry techniques in literature and inlaboratory. Hands-on experienceorganic chemistry synthesis techniquesincluding air- and moisture-sensitive reactions using Schlenk techniques and inert atmosphere conditions. Proficiencyinoperating analytical instrumentation such asHPLCandLC-MSwith the ability tointerpret results from data acquisition. Strong analytical chemistryskills usingLC-MS, NMR, IR, UV/Vis, TLC,and related techniques. Experience in chemoenzymatic reactions isaplus. Strong documentation and scientific communication skills. Strong senseof teamwork, flexibility, and enthusiasm for advancingnew technologies. Education B.S. or M.S. inorganic chemistry, nucleotide/nucleic acid chemistry, bioorganic chemistry, or related discipline. 5–8yearspost-B.S. or2-4 years post-M.S.of relevant industry experience inorganic chemistry,nucleic acid chemistry,medicinal chemistry, or related fields. Benefits & Perks Sarmal offers a competitive and comprehensive benefits package, including: Medical, dental, and vision coverage Company-paid life insurance 401(k) retirement plan Generous paid time off Access to additional voluntary benefits, employee perks, and discount programs We are committed to supporting the well‑being of our employees and providing a strong foundation for both professional and personal success. $72,000 - $85,000 a year California Pay Transparency Statement. The anticipated salary range for this position is $72,000 – $85,000, depending on experience and qualifications. Final compensation will be determined based on a variety of factors including, but not limited to, location, relevant experience, skill set, and internal equity considerations. EEO Statement Sarmal is an equal opportunity employer committed to building a diverse and inclusive workplace. We do not discriminate based on race, color, religion, sex, gender identity or expression, sexual orientation, national origin, ancestry, age, disability, medical condition, genetic information, marital status, veteran status, or any other characteristic protected by applicable federal, state, or local laws. Reasonable Accommodation Statement Sarmal is an equal opportunity employer that values diversity and inclusion. We welcome applicants of all backgrounds and consider all qualified candidates in accordance with applicable laws. Why Join Sarmal Work on cutting-edge genomics and molecular detection technologies Collaborate with a deeply technical, cross-functional team Contribute to foundational platform development at an early stage Have visibility into and impact on core technical and strategic decisions Help shape the infrastructure, culture, and future direction of the company Closing Statement Join us in advancing the next generation of genomic technologies and shaping the future of precision health. #J-18808-Ljbffr Sarmal Inc