Scientist 3 - CVRM Discovery / Research Biology

The Opportunity The CVRM (Cardiovascular, Renal, and Metabolism) Research Biology group within Genentech Research and Early Development (gRED) is seeking a highly talented, motivated, and creative Scientist 3 to investigate novel pathways, targets, and therapeutic development in metabolic disease. The Scientist3 contributes to the early‑stage cardiometabolic pipeline across multiple therapeutic modalities and disease areas, including obesity, cardiovascular, renal, and metabolic conditions. In this lab‑based role you will work independently and collaboratively to validate new targets and pathways, leveraging in vitro, ex vivo, and in vivo skills. Reporting to a Senior Principal Scientist, you will engage in target discovery and mechanism‑of‑action studies while collaborating with cross‑functional teams of scientists and clinicians to advance therapeutic development. Key Responsibilities Independent design, execution, and interpretation of experiments; including brainstorming of next steps and troubleshooting Mentoring and cross‑training colleagues Presenting research at intra‑ and inter‑departmental meetings Communicating findings through high‑quality internal presentations, cross‑functional forums, and external publications/conferences Ensuring timely adherence to the electronic lab notebook (ELN) Contributing to and maintaining a collaborative lab culture and safe environment Qualifications Education: PhD in a life science discipline (e.g., cell biology, biochemistry) or a Bachelor’s/Master’s degree with equivalent industry experience. Track Record: Demonstrated achievement through high‑quality publications and a strong understanding of cardiovascular and metabolic disease biology. Experimental Design: Skilled in independent, controlled experimental design and literature review to drive mechanism‑of‑action studies. Cell Culture: Proficient in culturing mammalian cell lines and primary cells (cardiomyocytes, immune cells, organoids, etc.). Molecular Methods: Experienced in cell line manipulation (e.g., CRISPR, shRNA, lentivirus) and characterization (e.g., qRT‑PCR, RNAseq, Western Blot, ELISA). Tissue Analysis: Capable of ex‑vivo tissue isolation and downstream processing (e.g., protein/RNA isolation). Assay Proficiency: Competent in plate‑reader based assays, reporter assays, dose‑response curve generation, and statistical analysis. Communication: Strong interpersonal skills with the ability to present research in cross‑functional forums. Preferred Background and Skills Experience with imaging technologies (e.g., Incucyte, immunofluorescence), flow cytometry, and protein methods (e.g., IP). Industry experience, familiarity with cardiovascular models, and experience or willingness to develop in vivo models. Additional Information Location: South San Francisco, CA campus (onsite presence required). Relocation benefits are available for this position. Expected salary range based on the primary location: $103,400 to $192,000. Compensation will be determined based on experience, qualifications, geographic location, and other job‑related factors. A discretionary annual bonus may be available. Benefits Genentech is an equal opportunity employer. We promote, employ, and treat all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to discrimination on the basis of protected veteran status, individuals with disabilities, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing the Accommodations for Applicants form. #J-18808-Ljbffr F. Hoffmann-La Roche AG