Senior Scientist, Fermentation - IR&D, Product Development

Senior Scientist, Fermentation - IR&D, Product Development About SiteCatalent’s Baltimore site is a leading facility specializing in biologics development and manufacturing, offering state-of-the-art capabilities to support advanced therapies. The campus provides a collaborative environment where teams work on innovative solutions for clinical and commercial supply, including cell and gene therapies. With modern laboratories and manufacturing suites, the site is designed to foster scientific excellence and operational efficiency. Employees here are part of a dynamic setting that emphasizes quality, innovation, and patient-focused outcomes, making it an exciting place to contribute to life-changing medicines.Position SummaryWe have an opportunity for a Senior Scientist, Fermentation - IR&D, Product Development to join our team. This role supports process and product innovation to keep Catalent at the forefront of leading CDMOs. You will work on upstream fermentation development, clone selection, and technology improvements for novel vectors. The position involves collaboration with internal teams and clients, contributing to innovative solutions for advanced therapies.Shift: Monday - Friday 8AM - 5PMLocation: Baltimore, MD - BioPark100% OnsiteThe RoleLead platform fit assessment for novel vectors (IR&D) and optimize upstream fermentation conditions.Execute clone selection using DASGIP (4x1L) and Eppendorf BioFlo systems to identify candidates for RCB and eventual GMP MCB generation.Perform strain selection across E. coli hosts to ensure plasmid stability, integrity, and high yield.Evaluate novel plasmid vectors for AAV/lentiviral production via shake-flask transfection studies.Conduct transfection, cloning, and high-throughput screening (ambr15 48‑bioreactor system) to identify top-performing clones.Tech transfer clone-specific fermentation processes to Process Development and GMP manufacturing (UpTempo and custom client vectors).Drive innovation by improving strain selection, fermentation processes, media, and lysis strategies.Maintain plasmid inventory, oversee fermentation lab operations, and support critical equipment ownership.Troubleshoot technical challenges while collaborating cross-functionally, communicating with stakeholders/clients, and mentoring junior team members.Other duties as assigned.The CandidateMinimum RequirementsPhD degree with 4+ years of upstream process development/R&D, or Master’s degree with 8+ years, or BA/BS with 10+ years in upstream process development/R&D. Education must be in a biological, scientific, or engineering discipline (biology, biochemistry, chemical engineering, or equivalent).Experience with a wide array of E. coli strains including Dh5, DH10b, NEB, Stbl.Excellent problem-solving and written/verbal communication skills.Strong interpersonal skills and ability to work effectively within a team.Ability to execute detailed experimental plans, record procedures, analyze data, and present results.Proficient in MS Office, specifically Excel and Word, and programs for laboratory equipment.Ability to sit at a desk or computer for periods of time to prepare documentation, reports, and data analyses.Ability to work in a laboratory environment for extended periods, including standing, walking, or sitting.Manual dexterity to safely and accurately handle laboratory instruments, pipettes, chromatography equipment, and various tubing and fittings.Occasional lifting of containers or lab equipment weighing up to 30 pounds.Good vision and hand-eye coordination for detailed work.Use of personal protective equipment (PPE) including lab coats, gloves, safety goggles, and, when required, respiratory protection.Preferred Skills & BackgroundExperience with mammalian cell types including HEK293, CHO, and others is a plus.Scale-up of fermentation or cell-culture processes to 50L+ bioreactor scale is a plus.Experience with preparation of regulatory documents is a plus.Experience with various cell lines for recombinant protein and gene therapy vector expression, process development, and/or bioprocess manufacturing is a plus.PayThe anticipated salary range for this position in MD is $120,000 – $150,000 Plus Bonus. The final salary offered to a successful candidate may vary, and will be dependent on several factors that may include but are not limited to: the type and length of experience within the job, type and length of experience within the industry, skillset, education, business needs, etc. Catalent is a multi-state employer, and this salary range may not reflect positions that work in other states.Why You Should Join CatalentBiologics services include process development, analytical development, quality systems, stability studies, fill/finish, and cell and virus banks.Featured technologies include adeno-associated virus (AAV), vaccines, and oncolytic virus.152 hours PTO plus 8 paid holidays.Medical, dental, and vision coverage options.Generous 401(k) match.Tuition reimbursement.Catalent offers rewarding opportunities to further your career! Join the global drug development and delivery leader and help us bring over 7,000 life-saving and life-enhancing products to patients around the world. Catalent is an exciting and growing international company where employees work directly with pharma, biopharma and consumer health companies of all sizes to advance new medicines from early development to clinical trials and to the market. Catalent produces more than 70 billion doses per year, and each one will be used by someone who is counting on us. Join us in making a difference. personal initiative. dynamic pace. meaningful work.Visit Catalent Careers to explore career opportunities.Catalent is an Equal Opportunity Employer, including disability and veterans.If you require reasonable accommodation for any part of the application or hiring process due to a disability, you may submit your request by sending an email, and confirming your request for an accommodation and include the job number, title and location to View email address on click.appcast.io. This option is reserved for individuals who require accommodation due to a disability. Information received will be processed by a U.S. Catalent employee and then routed to a local recruiter who will provide assistance to ensure appropriate consideration in the application or hiring process.Notice to Agency and Search Firm Representatives: Catalent Pharma Solutions (Catalent) is not accepting unsolicited resumes from agencies and/or search firms for this job posting. Resumes submitted to any Catalent employee by a third party agency and/or search firm without a valid written & signed search agreement, will become the sole property of Catalent. No fee will be paid if a candidate is hired for this position as a result of an unsolicited agency or search firm referral. Thank you.Important Security Notice to U.S. Job Seekers:Catalent NEVER asks candidates to provide any type of payment, bank details, photocopies of identification, social security number or other highly sensitive personal information during the offer process, and we NEVER do so via email or social media. If you receive any such request, DO NOT respond— it is a fraudulent request. Please forward such requests to View email address on click.appcast.io for us to investigate with local authorities.California Job Seekers can find our California Job Applicant Notice HERE.SummaryLocation: Baltimore, MDType: Full time