Protein Purification Scientist

We are seeking a highly motivated Protein Purification Scientist to support neurodegeneration drug discovery programs within the NeuroImmune group. The successful candidate will be responsible for the purification, quality control, and delivery of human brain-derived Tau protein to support research aligned with the neurodegeneration portfolio. This role requires strong hands‑on expertise in protein biochemistry, purification from tissue samples, molecular and cell biology techniques, and assay execution. The scientist will work closely within a collaborative team environment, generating high‑quality data, maintaining accurate records, and communicating results effectively to project stakeholders. Key Responsibilities include: Execute Tau protein purification from human brain tissue using established protocols. Perform end‑to‑end purification workflows, including protein isolation, enrichment, quality control, and final product delivery. Conduct analytical and functional assays, including: HTRF assays, MSD assays, Western blotting, RT-qPCR, ELISA‑based assays, and High‑content imaging. Perform and maintain aseptic cell culture‑procedures. Support iPSC‑derived neuronal culture experiments as required. Analyze, interpret, and present experimental data to project teams and management. Maintain accurate and timely documentation in electronic laboratory notebooks (Signals ELN). Required Skills & Experience PhD in Biochemistry, Neuroscience, Molecular Biology, Cell Biology, or a related scientific discipline preferred. Candidates with a Master's degree and relevant industry experience will also be considered. Demonstrated hands‑on protein purification experience, preferably from tissue‑derived samples. Experience performing: Western blotting, RT-qPCR, Aseptic mammalian cell culture, HTRF and/or MSD assays. Ability to work onsite 5 days per week in Upper Providence, PA. Nice to Have Skills & Experience Experience working with human brain tissue. Experience purifying Tau protein or other aggregation‑prone proteins associated with neurodegenerative diseases. Hands‑on experience with iPSC‑derived neuronal cultures. Compensation $40‑50/hr on W2. Exact compensation may vary based on several factors, including skills, experience, and education. Employees in this role will enjoy a comprehensive benefits package starting on day one of employment, including options for medical, dental, and vision insurance. Eligibility to enroll in the 401(k) retirement plan begins after 90 days of employment. Additionally, employees in this role will have access to paid sick leave and other paid time off benefits as required under the applicable law of the worksite location. #J-18808-Ljbffr