Principal Scientist, Process Chemistry

Role Summary The Chemical Process and Analytical Development (CPAD) group located in Bothell, WA is responsible for the development of chemical processes and analytical methods for novel drug‑linkers used in antibody‑drug conjugates (ADCs). As a Principal Scientist in CPAD you will provide technical leadership to process chemists engaged in route screening/selection, process development, and process characterization for our growing drug‑linker portfolio. You will drive development of safe and scalable chemistry using high‑throughput experimentation, data‑rich experimentation, catalysis, continuous processing, and predictive technologies. You will oversee technology transfer and campaign execution at CDMOs, mentor junior staff, and establish an external presence by authoring journal articles and presenting at scientific meetings. Role Responsibilities Design and execute well‑planned laboratory experiments requiring complex data analysis. Maintain high standards for laboratory records, reports, patents, regulatory documents, and external communications. Employ state‑of‑the‑art technologies including high‑throughput experimentation, data‑rich experimentation, computational tools, and predictive software to accelerate process development. Be recognized as a technical leader internally and externally by authoring publications and presenting at conferences. Drive technical aspects of early and late phase pharmaceutical development. Lead technology transfer to internal sites or external CDMOs for GMP manufacturing while managing CRO/CMO resources. Communicate abstract concepts, ideas, and solutions persuasively to project teams, leadership, and cross‑functional teams. Establish and deliver on tight timelines aligned with portfolio goals. Promote a supportive and inclusive work environment and mentor junior staff. Maintain an understanding of the activities and research carried out by project team members. Lead authoring for patents and regulatory documents. Leverage knowledge and experience to guide cross‑functional team decisions. Build strong relationships with stakeholders to advocate for the department. Basic Qualifications PhD in Organic Chemistry with 4+ years of experience in pharmaceutical process development, including route design, scale‑up, and GMP manufacturing; or Master’s degree with 9+ years of relevant experience; or Bachelor’s degree with 12+ years of experience. Proven track record of scientific innovation demonstrated through peer‑reviewed publications, patents, or presentations at recognized conferences. Sound understanding of modern synthetic organic chemistry principles, process development, engineering, analytical, and purification technologies. Excellent written and oral communication skills with demonstrated ability to collaborate with stakeholders. In‑depth knowledge of pharmaceutical development from pre‑clinical to commercialization. Experience in a regulated pharmaceutical environment including GMP deliveries and regulatory authoring. On‑site designated role; expected to work five days per week on‑site. Preferred Qualifications Experience with drug‑linkers for ADCs or other targeted mixed‑modality therapeutics. Experience mentoring scientific staff directly and in a matrix environment. Experience with technology transfer activities and CRO/CDMO resource management. Physical/Mental Requirements Lifting, sitting, standing, walking, bending and performing mathematical calculations. Non‑standard Work Schedule, Travel or Environment Requirements Laboratory‑based; adherence to safe work practices and PPE required. Occasional travel for business purposes, scientific conferences, or collaboration (typically Location Bothell, WA (On Premise) Compensation & Benefits Annual base salary ranges from $106,000 to $176,600. Eligible for Pfizer's Global Performance Plan with a bonus target of 15% of base salary and participation in our share‑based long‑term incentive program. Comprehensive benefits include 401(k) with matching contributions, paid vacation, holiday and personal days, caregiver/parental and medical leave, and health, prescription drug, dental and vision coverage. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E‑Verify employer. This position requires permanent work authorization in the United States. #J-18808-Ljbffr Pfizer, S.A. de C.V