Senior Principal Scientist, Applied AI & Agentic Systems for Small-Molecule Drug Discovery
$168k - $252kVertex Pharmaceuticals
Vertex Pharmaceuticals seeks a senior scientific leader to advance artificial intelligence and agentic systems in small-molecule drug discovery. This role bridges computational drug design, data science, and engineering to develop AI-enabled workflows that enhance molecular design, hypothesis generation, and decision-making across the discovery-to-analysis cycle.
Responsibilities
- Drive strategic application of AI and agentic systems across small-molecule drug discovery and related modalities
- Partner with project teams to develop and deploy AI co-scientists supporting design, analysis, and lead optimization
- Define scientific evaluation frameworks and establish success metrics for AI-enabled workflows
- Serve as scientific bridge between Drug Discovery, Data & Methods, and Digital Technology & Engineering teams
- Lead adoption through scientist engagement, education, and change management while ensuring responsible AI compliance
Requirements
- Ph.D. in Computational Chemistry, Chemistry, Computer Science, Data Science, Engineering, or related discipline
- 8+ years applying computational chemistry and cheminformatics to small-molecule drug discovery programs
- Deep expertise in computational chemistry, cheminformatics, machine learning, or scientific data science
- Strong understanding of large language models, agentic systems, and AI-assisted scientific applications
- Demonstrated ability to define evaluation frameworks and validation strategies for AI research tools
- Proven track record leading cross-functional initiatives and driving organizational transformation
- Experience with protein therapeutics or emerging therapeutic modalities strongly preferred
Vacancy posted 22 days ago
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