Scientist - Cardiometabolic Disorders

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. R-242106 Scientist - Cardiometabolic Disorders What you will do Let’s do this. Let’s change the world. In this vital role you will commit to develop a deep understanding of the causal pathogenic mechanisms that drive Obesity and Obesity-Related Comorbidities. Key Responsibilities: Work collaboratively with a team of experts to conduct laboratory experiments to generate robust data supporting the preclinical validation of new therapeutic targets. Independently design, execute, and interpret in vitro and ex vivo experiments, including troubleshooting, optimization of assays, data collection, interpretation, biostatistical analysis, and presentation. The scope of work will include testing and developing cell lines, conducting gene expression and protein abundance assays, establishing functional assays based on phosphorylation, oligomerization events, or other readouts using high-content imaging or medium throughput plate-based techniques used to support both small and large molecule drug development programs. Participation in cross-functional drug development teams as a key intellectual and technical contributor. The candidate is expected to be well-versed in the pathophysiology of Obesity and Cardiometabolic Diseases and to be continuously aware of scientific developments in this disease area, with emphasis on preclinical research methodologies and models. Present research discoveries to Amgen colleagues and scientific meetings (oral/poster presentations and publish scientific papers in peer-reviewed journals). Function optimally in a team based/collaborative environment as part of a highly integrated team, possess excellent organizational, verbal, and written communication skills and demonstrate ability to produce reliable and reproducible results. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The dedicated laboratory scientist we seek is a professional with these qualifications. Basic Qualifications: Doctorate degree OR Master’s degree and 2 years of experience in Cardiovascular research or related discipline OR Bachelor’s degree and 4 years of experience in Cardiovascular research or related discipline Preferred Qualifications: A PhD in a relevant field with 0-2 years of experience. A MS in a relevant field with 5+ years of experience. Ideal candidates should have broad experience working with models of cardiometabolic disease, both in vitro and in vivo. Ability to perform in vitro assays to dissect the mechanism of action of therapeutic molecules in cardiac myocytes, fibroblasts, adipocytes, endothelial cells, and other relevant cardiometabolic cell types. Ideal candidates should have in vitro experience with cultured cell lines, siRNA transfection techniques, western blotting, quantitative PCR techniques, RNA/DNA isolation, laboratory automation, high content imaging technology, and fluorescence microscopy. Demonstrated excellence working in a team environment and possessing good laboratory documentation skills. What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. Sponsorship Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. #J-18808-Ljbffr Amgen SA