IT Support Specialist, Tier II - US based

Location: This position may be performed remotely, but requires the flexibility and willingness to travel as needed. The Opportunity The Tier II IT Support Specialist is a key player in delivering seamless technology experiences across Praxis. You’ll serve as the primary escalation point for complex technical issues, partnering closely with our internal IT support, development, and leadership teams to ensure smooth operations for our 260–400 users. From managing identity and access to administering collaboration platforms and overseeing IT assets, this role is essential to sustaining and scaling our tech infrastructure. This is a hands-on, high-impact position for someone who thrives on solving problems, documenting what works, and improving how we support our mission. Primary Responsibilities Serve as the go-to escalation point for Level 2 IT issues from our internal Helpdesk Troubleshoot and resolve complex problems across Microsoft 365, collaboration tools, and endpoint devices Support onboarding and offboarding workflows for employees, consultants, and contractors Administer user access and authentication across Microsoft Entra ID and SaaS platforms Manage SSO, MFA, password managers (1Password), certificates, and guest access Handle admin consent requests and configure access for contractors and temporary roles Administer permissions for SharePoint, DocuSign, Zoom AI, Atlassian, and other SaaS tools Conduct periodic license reviews and audits across enterprise applications Oversee laptop shipping, imaging, and inventory tracking in Jira Manage conference room AV systems and recordings for company-wide meetings as needed to support vendors Respond to security-related alerts and support access to secure systems and VPNs Partner with vendors and internal teams to manage OEM support and renewals Maintain IT knowledge base in Confluence and refine workflows Proactively identify and implement improvements to enhance support quality and user experience Qualifications and Key Success Factors Bachelor’s degree in IT, Computer Science, or related field—or equivalent hands-on experience 5+ years in Tier II support, service desk, or IT operations roles Strong experience with Microsoft 365, Entra ID, N-Central and identity/access systems Familiarity with Jira Service Management and Confluence is a plus Comfortable supporting SaaS platforms and collaboration tools Exceptional troubleshooting, documentation, and communication skills A proactive, collaborative mindset with the ability to operate independently Flexibility for occasional after-hours or on-call support The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions. Annualized Base Salary

$68,000—$88,000 USD

Company Overview Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members. Diversity, Equity & Inclusion Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws. Attention: Job Scam Alert Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to View email address on click.appcast.io. Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.