SVP Clinical Development & Global Program Lead, Pancreatic Cancer

SVP Clinical Development & Global Program Lead, Pancreatic Cancer

Erascais a clinical-stage precision oncology company focused on discovering, developing and commercializing medicines for the benefit of patients with cancer. Our programs take novel approaches to shutting down one of cancer’s most commonly mutated signaling cascades, the RAS/MAPK pathway, which affects approximately 5.5 million lives each year worldwide. The name “Erasca” has an important embedded meaning: it is a contraction of our audacious hope to “erase cancer” that drives our mission and everything that we do on behalf of patients with cancer.

Position Summary

Reporting to the Chief Medical Officer, the VP Clinical Development and Global Program Lead (GPL) for GI Cancers will provide medical leadership and oversight of the pancreatic and colorectal cancer development programs and collaborate with the CMO across the Erasca portfolio. Responsibilities will include clinical development strategy, protocol development, registrational strategy and execution, KOL and academic site interactions, competitive landscape diligence, presentation of data, and other clinical deliverables. In addition, the VP will be a hands–on drug developer and will serve as clinical lead and/or medical monitor on individual studies.

Essential Duties and Responsibilities

• Providemedical direction and high-quality scientific and clinical knowledge to guide the strategy and execution ofthe pancreatic and colorectal can cer programs and contribute to clinical decision making across the Erasca portfolio. Participate in building and maintaining a culture of rigorous data-driven decision making.
• Lead the clinical development subteam for all studies in GI cancers.
• Design and implementnovel and efficientclinical trialstoassessappropriate endpoints.
• Responsible for leading clinical studysubteams,monitoringoverall study integrity, and review, interpretation,and communication of safety and efficacy data.
• Provide overall strategy for clinical aspects of registrational strategies, interactions, and filings. Contribute to global regulatory filings and health authority interactions, including authoring clinical sections for INDs,NDAsand other related documents.
• Serve asMedicallead on clinical programsand r epresent Clinical Development on program teams.
• Partner with Drug Safety to assess the safety profile of compounds.
• Writeor partner in the authoring ofmedical aspects of core study and regulatory documents including clinical research plans, protocols, investigator brochures, clinical studyreportsand regulatory submissions.
• Contribute to the development and review of scientific publications; author manuscripts and collaborate with cross-functional colleagues and thought leaders to meet publication planobjectives.
• Present at scientific, medical,and regulatory meetings.
• Maintaina high levelof clinical and scientificexpertiseby reviewing literature, attending medicalorscientific meetings,and through personalexchangewiththought leaders, investigators,and internal stakeholdersand partners.
• Participate in due diligence or other business development activities.
• Hire, develop, and mentor a high functioning team of medical directors and clinical scientists.
• Establish, develop,andmaintainrelationships across Erasca, particularly with partners and stakeholders inResearch andDevelopment.
• Perform all duties in keeping with the Company’s core values,policiesand all applicable regulations.

Required Education and Experience

• M.D.degreeor equivalent, with subspecialtyfellowshiptraining and board certification or eligibility in Oncology or Oncology/Hematologyrequired.
• 8-10+ years ofoncologyclinical trial anddrug development experience,including extensive experience in the pharmaceutical or biotechnology industry.The ideal candidate will bringa combination of clinical practice, academic clinical trials,and industry experience,withbothlarge and small companyexperiencea plus.
• Experience as the clinical lead on late-stage clinical programs in colorectal, pancreatic, or other GI cancers required .
• Experience leading or beingclosely involvedinthe clinical aspects of aregulatory filing and direct interaction with health authoritiesrequired.
• Exposure to early development and the transition from FIH to registrational trials preferred.
• Extensive knowledge of clinical trialmethodologyand theregulatory and compliance requirements governing clinical trials.
• Demonstrated ability to collaborate successfully with multiple functions in amatrixedteam environment.
• Executive leadership skills to educate and influence stakeholders and to add valueinstrategic business planning and decision-making.
• Effective interpersonal, communication and influencing skills, including excellent writing skills, with the ability to tailor communication style to diverse audiences and situations.
• Demonstrated ability to achievehigh performancegoals and meet deadlines in a fast-paced environment; a collaborative team player with a can-do attitude and the ability toidentifyand implement creative solutions to complex problems.
• Strong learning orientation, curiosity, andcommitment toscience and patients.

The anticipated salary range for this position is $390,000 to $435,000 . The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc etera. In addition to base salary, the h ired applicant will be eligible to receive an annual bonus and an equity grant at hire and annually in the form of the option to purchase stock in the future for a specified price.

Benefits

• Paid Time Off , Holiday , and Sick Leave , Medical, Dental and Vision Plans , Short- and Long-Term Disability , Basic and Voluntary Life/AD&D Coverage , Flexible Spending Account s (FSA , HSA, and Commute ) , Critical Illness and Accident Coverage , Pet Insurance, Employee Assistance Program , 401(k) Plan with Erasca contribution , and the opportunity to participate in an E mployee S tock P urchase P rogram.

Erasca, Inc., is an Equal Opportunity Employer and takes pride in maintaining a diverse and inclusive environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of sex , race, religion, national origin, ancestry, physical or mental disability, protected medical condition, genetic information, marital status, registered domestic partner status, age, sexual orientation, military and veteran status or any other basis protected by federal, state or local law or ordinance or regulation.