Associate Principal Scientist, Discovery Oncology

Overview We are seeking a highly motivated and innovative Associate Principal Scientist to join our Discovery Oncology team in South San Francisco. The successful candidate will have a strong track record in oncology and drug discovery and will lead the conception, design, and execution of discovery‑stage research programs. In this role, you will partner closely with cross‑functional teams across the organization to advance differentiated cancer therapies from target validation through early development. Key Responsibilities Design, establish, and optimize in‑vitro and ex‑vivo assays to elucidate mechanisms of action and assess therapeutic potential. Make timely, data‑driven decisions that balance innovation, risk, and experimental rigor. Communicate scientific strategy, rationale, and results clearly to internal teams and help build external scientific presence through publications, conference presentations, and collaboration. Drive ideation and early‑stage discovery efforts to deliver competitive oncology programs, leveraging internal expertise and emerging technologies. Qualifications Education: Ph.D. in Cancer Biology, Cell Biology, Pharmacology, Immunology, Biochemistry, or a related discipline with four (4) or more years of relevant oncology drug discovery experience. Deep expertise in tumor biology and immune oncology, including cancer genomics and oncogenic signaling. Broad technical expertise in molecular and cellular biology, biochemistry, and analytical methods. Extensive hands‑on in‑vitro experience designing, executing, and analyzing multi‑color flow cytometry and mechanistic cell‑based assays (e.g., viability/cytotoxicity, cell cycle, signaling, and immune response readouts). Demonstrated ability to drive innovative research, evidenced by high‑impact publications, patents, and/or successful advancement of discovery programs. Passionate, creative, and collaborative scientist committed to improving outcomes for people living with cancer. Excellent oral and written communication skills, a positive, team‑oriented mindset, and strong leadership potential. Preferred Experience and Skills Hands‑on experience with different therapeutic modalities (e.g., small molecules, mAbs, ADCs, and TCEs). Extensive hands‑on experience designing, executing, and analyzing in‑vivo mouse model data to evaluate therapeutics. Biochemistry, Cancer Cell Biology, Cancer Research, Cell Biology, Immuno‑Oncology, In‑Vitro Biology, In‑Vitro Research, Molecular Biology, Oncology, Tumor Biology skills. Salary & Benefits The salary range for this role is $159,600.00 – $251,200.00. The successful candidate will be eligible for annual bonus and long‑term incentive, if applicable. We offer a comprehensive package of benefits which includes medical, dental, vision, and other insurance benefits for employee and family; retirement benefits including 401(k); paid holidays, vacation, and compassionate and sick days. Equal Employment Opportunity As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit the EEOC and GINA Supplement. #J-18808-Ljbffr