Postdoctoral Fellow - Translational Safety, Complex in vitro Systems Lab (Neuro)

The Position A healthier future. It's what drives us to innovate to continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech. A postdoctoral research fellow position is available in the Neural functional lab within the Complex in Vitro Systems' Neuroscience group at Genentech. Our laboratory is dedicated to developing next generation complex in vitro models of the healthy and degenerative central nervous system to generate new insights into disease biology and emerging therapies. We have a particular interest in understanding and perturbing microglial contributions to neurodegeneration using high-throughput screening state-of-the-art omics techniques. The Opportunity: To lead an independent, end-to-end translational research program developing an multicellular in vitro model of the brain and resident immune cells in a neurodegenerative (Alzheimer's) disease state, and investigating the phenotypic responses to changes in therapeutic or pathologic gene perturbation in separate cellular compartments. To leverage state-of-the-art omics techniques and develop screening methods for complex in vitro models. To collaborate widely and cross-functionally with colleagues at Genentech, including molecule development teams, Neuroscience Research, and Development Sciences. To participate in Genentech's postdoctoral training program, which offers outstanding training and mentorship, opportunities to present work internally and externally, career development support, and exposure to an environment focused on drug development and breakthrough discoveries. Who You Are: You have a Ph.D. in Neuroscience, Bioengineering, Systems Biology or related with a proven track record of high impact research accomplishments. You have advanced at least one project as evidenced by a first author paper published or accepted in a leading peer-reviewed journal. You are a highly independent and driven scientist who enjoys working at the bench and the computer. You have a strong passion for scientific research. Knowledge and experience in modeling of human neurodegenerative disease, e.g. Alzheimer's disease. Ability to learn, adapt, and apply computational tools as part of an experimental research program. You value careful experimental design, quantitative rigor, and clear biological interpretation. You communicate effectively and thrive in a collaborative, interdisciplinary environment. Preferred Qualifications: Experience in developing neurodegenerative disease models in complex in vitro systems (organoids, spheroids, organ-on-chip, etc) is highly desirable. Experience in generating and deploying high-throughput methods for drug and genetic screening is highly desirable. Experience with generating and analyzing single-cell transcriptomic or multi-omic data (e.g., scRNA-seq, ATAC-seq, proteomics) is preferred. The expected salary range for this position based on the primary location of South San Francisco California is $100,00 to $106,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for the benefits detailed at the link provided below. Benefits Relocation benefits are available for this job posting. Postdoc Program Elevate your research career to new heights with Genetech's Postdoctoral Program! Join a prestigious community of early career scientists and kick-start your journey toward becoming a scientific leader in biotechnology and bioengineering. With competitive salaries and fully funded research expenses, you can dedicate yourself to groundbreaking research that aligns with Genentech strategic ambitions. The postdoc program is designed to empower recent Ph.D. graduates to conduct world-class research, publish in top-tier journals, and build a robust scientific network. By joining us, you will receive the mentorship and support necessary to develop into an independent scientist and leader. The Genentech Postdoc Program provides access to world-class seminars, professional development workshops, and networking opportunities. Apply now to Genentech's Postdoctoral Program and unlock your full potential! #LI-PL1 #postdoc Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants .