Bioinformaticist - Population Genetics

Bioinformatician - Population GeneticsLocation: Remote Contract: Short Term ContractBigR.io is a remote-based, technology consulting firm with headquarters in Boston, MA. We deliver software solutions ranging from custom development, software implementation, data analytics, and machine learning/AI integrations. Our thought-forward, Big Data team is working on a number of data architecture and software-solution projects. You will join this high-caliber team as a Technical Consultant who will work with our clients to implement software-based solutions to fit their needs.BigR.io is looking for a Synthetic CRISPR-Cas RNP Bioinformaticist with strong Population Genetics experience to review publicly available data sets and direct our client toward effective research paths. The goal is to identify sequence polymorphisms that differentiate the pathogenic from healthy alleles with their relative frequencies in the general population and to develop a therapeutic approach that can selectively target and modify the pathogenic allele without affecting the healthy allele.Responsibilities:Analyze publicly available data from genome-wide association studies to identify sequence polymorphisms that differentiate the pathogenic from healthy alleles of HTT and ATXN3Design and develop specific spacers outside of the CAG repeat sequence for the pathogenic alleles of HD and SCA3 using programmable nucleases called Cas enzymesDevelop a therapeutic approach that can selectively target and modify the pathogenic allele without affecting the healthy alleleWork collaboratively with other researchers and developers to optimize the CRISPR-Cas RNP system for the treatment of HD and SCA3Ensure accuracy of protein and RNA data analysis and interpretationDocument and present findings in scientific meetings and publicationsRequirements:Ph.D. in molecular biology, genetics, or a related fieldStrong background in genome editing technologies, particularly CRISPR-Cas systemsExperience in analyzing genomic data from large datasets, including genome-wide association studiesFamiliarity with molecular biology techniques, including gene expression analysis, protein and RNA analysis, and cloningExperience in working with cell culture systems, including primary human cellsStrong communication and interpersonal skillsAbility to work collaboratively in a multidisciplinary teamPreferred Qualifications:Experience in developing CRISPR-based therapeutics for monogenic disordersKnowledge of Huntington's Disease and Spinocerebellar Ataxia 3 pathophysiologyExperience in animal models of HD and SCA3Strong track record of scientific publications and presentations