Scientist, Global Medical Research

About PharmaEssentia PharmaEssentia Corporation is a global biopharmaceutical company with a pioneering spirit and a deep commitment to patients with rare and underserved diseases. Our lead product, BESREMi® (ropeginterferon alfa-2b), is the first FDA‑approved monotherapy for polycythemia vera (PV) regardless of treatment history, and we are actively advancing our clinical and real‑world evidence programs across myeloproliferative neoplasms (MPNs), including essential thrombocythemia (ET) and myelofibrosis (MF). Our pipeline includes landmark studies such as EXCEED‑ET and HOPE‑PMF, alongside a growing portfolio of investigator‑initiated trials (IITs) and real‑world evidence initiatives. The Opportunity We are seeking a Scientist, Global Medical to serve as a key driver of our evidence generation strategy. This role sits at the intersection of clinical research, investigator‑initiated trials, and scientific publication—translating medical strategy into published evidence that shapes clinical practice and supports guideline development. The ideal candidate is an accomplished clinical researcher with a strong publication track record, deep experience in hematology or oncology, and the ability to independently advance complex research programs from concept through publication. Investigator‑Initiated Trial (IIT) Management Lead oversight of the IIT portfolio, from concept evaluation and scientific review through study monitoring, data interpretation support, and publication collaboration Develop and apply rigorous evaluation criteria for IIT proposals, assessing strategic alignment, scientific merit, investigator credibility, institutional track record, and feasibility Serve as the primary scientific liaison with external investigators, providing scientific input on protocol design, supporting regulatory compliance awareness (CTA, IRB/EC approvals), and tracking study milestones Coordinate internal IIT governance processes, including concept review committees, budget and fair market value assessments, and fund disbursement oversight Establish and maintain a structured IIT pipeline tracker with clear stage‑gating, timelines, and deliverable expectations Clinical Trial Design & Evidence Generation Provide scientific input on the design and execution of company‑sponsored Phase IIIb/IV and adaptive clinical studies, burden of illness studies, and real‑world evidence programs Collaborate with clinical development, biostatistics, and regulatory teams on study design, endpoint selection, and statistical analysis plans Identify evidence gaps aligned with medical strategy and develop research plans to address them through RCTs, RWE, and health outcomes research Evaluate and integrate multiple real‑world data sources—including medical records, insurance databases, prescription databases, and patient registries—into the evidence generation strategy Scientific Publication & Dissemination Drive a publication strategy that produces high‑impact manuscripts, congress abstracts, poster presentations, and review articles across the PV, ET, and MF therapeutic areas Author, co‑author, and critically review manuscripts for submission to peer‑reviewed journals, ensuring factual accuracy, scientific rigor, and compliance with ICMJE and GPP guidelines Collaborate with KOLs and academic investigators to develop consensus guidelines, journal supplements, and Delphi consensus study outputs Ensure all publications align with the integrated evidence plan and support NCCN guideline submissions and payer evidence needs Cross‑Functional Collaboration & Scientific Leadership Partner with the MSL team, Medical Affairs leadership, and Commercial Analytics & Insights to translate field insights and medical questions into actionable research hypotheses Support the development and maintenance of a medical question (CQ) map that links KOL insights, evidence gaps, and ongoing research activities Contribute scientific expertise to advisory boards, speaker programs, and internal training initiatives Prepare evidence summaries and data packages for executive leadership and regulatory interactions Required Qualifications MD, PhD, or MD/PhD from an accredited institution; terminal degree strongly preferred Minimum 5 years of clinical research experience at a top‑tier US academic medical institution or equivalent research‑intensive environment Demonstrated publication track record with first‑author or senior‑author peer‑reviewed publications in hematology, oncology, or a closely related field Direct experience managing investigator‑initiated trials, including protocol development, IRB/EC submissions, and investigator engagement Deep understanding of clinical trial design, biostatistics, and real‑world evidence methodologies Strong knowledge of regulatory requirements for clinical research, including ICH‑GCP, ICMJE, and GPP guidelines Proven ability to work independently, manage multiple complex projects simultaneously, and drive programs to completion with minimal supervision Excellent scientific writing skills with the ability to translate complex clinical data into clear, publication‑ready manuscripts and evidence summaries Preferred Qualifications Clinical or research background in hematology/oncology, with specific experience in myeloproliferative neoplasms (PV, ET, MF) or interferon‑based therapies Prior pharmaceutical or biotech industry experience in Medical Affairs, clinical development, or evidence generation roles Experience with NCCN guideline submissions or other clinical guideline development processes Experience designing and executing Delphi consensus studies or structured expert elicitation programs Familiarity with health economics and outcomes research (HEOR) and value‑based evidence frameworks Track record of successful collaboration with KOLs and external academic investigators Bilingual capabilities (English and Mandarin) are a plus but not required The expected salary range for this position based on greater Boston, MA location is $150,000-$205,000. Actual salary pay will be based on multiple factors, including geographic location, experience, qualifications, and other job‑related factors permitted by law. What We Offer A high‑impact role with direct visibility to executive leadership and the opportunity to shape the evidence strategy for a first‑in‑class therapeutic across multiple indications Ownership of a growing IIT portfolio and publication pipeline in an organization committed to scientific excellence and evidence‑based medicine A collaborative, intellectually rigorous Medical Affairs team with a compliance‑first culture and clearly defined governance structures Competitive compensation, comprehensive benefits, and the flexibility of a remote‑first working environment Benefits Of Working With Our Team PharmaEssentia USA strives every day to improve the lives of patients as well as our employees. As a valued member of PharmaEssentia USA, you will enjoy the following benefits: Comprehensive medical coverage Dental and vision coverage Generous paid time‑off 401(k) retirement plan with competitive company match Medical & Dependent Care Flexible Spending Account Up to $150 monthly cell phone reimbursement Employee Assistance Program Equal Employment Opportunity Statement At PharmaEssentia USA, we are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants without regard to race, color, religion, sex, pregnancy (including childbirth and related medical conditions), national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information (including characteristics and testing), military and veteran status, and any other characteristic protected by applicable law. PharmaEssentia USA believes that diversity and inclusion among our team are critical to our success as a global company, and we seek to recruit, develop and retain the most talented people from a diverse candidate pool. PharmaEssentia does not accept unsolicited agency resumes. Staffing agencies should not send resumes to our HR team or to any PharmaEssentia employees. PharmaEssentia is not responsible for any fees related to unsolicited resumes from staffing agencies. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. At PharmaEssentia, our goal is to treat as many people with cancer as possible. That means challenging the status quo with better science that leads to better lives. By joining our team, you will not only expand your own possibilities, but you will contribute to expanding options for people with cancer. #J-18808-Ljbffr PharmaEssentia