Senior Scientist, Target Discovery & Biology - Functional Genomics

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity‑related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award‑winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Scientist, Target Discovery & Biology - Functional Genomics What you will do Let’s do this. Let’s change the world. In this vital role you will join the Target Discovery & Biology team in South San Francisco. This role will leverage functional genomics in disease‑relevant systems, including complex biological models from in vitro to in vivo, to advance target discovery and validation across Amgen’s therapeutic areas. Key Responsibilities Leverage functional genomics approaches across therapeutic areas to discover novel targets and address key biological questions Lead, support and execute projects from inception through target identification, validation and mechanism‑of‑action studies Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline What we expect of you We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a researcher with these qualifications. Basic Qualifications: Doctorate degree PhD OR PharmD OR MD [and relevant post‑doc scientific experience in Target Discovery & Biology] OR Master’s degree and 3 years of relevant scientific experience in Target Discovery & Biology OR Bachelor’s degree and 5 years of relevant scientific experience in Target Discovery & Biology Preferred Qualifications: Strong experience in molecular biology and cell engineering. Experience in complex and co‑culture in vitro models is a major plus Experience in executing large scale, complex, and/or in vivo genetic screens (particularly CRISPR‑based) and follow up validation studies. Track record of pushing the envelope on scale and technical feasibility is highly desirable Familiarity with data‑driven discovery approaches, including integration of genetic or multi‑omics insights Excellent organizational and communication skills, with the ability to drive cross‑site collaboration in a matrixed research environment Additional experience relevant to applying functional genomics approaches to new target discovery across diverse indications Track record of scientific productivity and innovation as demonstrated through career experiences, project outcomes and/or publications Track record of taking on new areas of research and biology with successful outcomes What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well‑being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan Stock‑based long‑term incentives Award‑winning time‑off plans Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. Sponsorship Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. #J-18808-Ljbffr Amgen SA