Principal Scientist - Fluorophore Chemistry & CMC

A well-funded clinical-stage biotech developing targeted therapies and imaging agents is hiring a synthetic organic chemist to own its fluorophore program end to end: from bench synthesis through GMP scale-up and CMC. This is a hands-on role with real ownership. You will design and make the dyes, and you will be the company's technical lead with its external CMC provider. What you'll do Design and synthesise novel fluorophores, with an emphasis on polymethine and near-infrared dyes Develop and optimise multistep synthetic routes, troubleshooting them from first principles Take molecules from bench through scale-up to GMP manufacture Act as the technical interface to the CMC provider: specifications, impurity control, batch records, campaign oversight Support IND-stage CMC documentation Work alongside the peptide and organic chemistry team on conjugation and bioconjugate chemistry What you'll need PhD in Organic Chemistry or a closely related field Demonstrable hands-on fluorophore synthesis: dyes you have made yourself, not purchased and conjugated GMP experience and working knowledge of the CMC section of a drug application Track record taking chemistry from laboratory scale to GMP manufacture Click chemistry and bioconjugation Excellent safety record with organic solvents, oxidising agents and flammables Someone who reasons past a failed reaction rather than stopping at "it doesn't work" #J-18808-Ljbffr Discover International