Staff Software Engineer
$210k - $260kDavid Joseph & Company
Job Description
Job Description
Staff Software Engineer
Our client is a seed-stage healthcare/life-sciences company building AI agents that automate clinical trial workflows — attacking one of the biggest bottlenecks in drug development. Backed by $7M+ in funding, the platform is already used across 400+ research sites. This is a founding tech-lead role on a small, high-impact engineering team.
The role: A hands-on Staff Software Engineer (8+ yrs) to be the technical anchor of a small team — writing and reviewing code daily while mentoring three junior engineers and establishing engineering best practices, and partnering with product, customer success, and founders to ship zero-to-one AI-powered products.
Responsibilities
- Own and build AI-powered products end-to-end (agentic workflows, LLM features with production evals)
- Technical lead and mentor for three junior engineers; set best practices for code review and process
- Partner with CTO, PM, and customer success to shape zero-to-one products
- Architect and deliver full-stack apps across frontend, backend, infra, and data pipelines
Must-have
- Tech lead / technical anchor experience on an engineering team
- Full-stack product engineer who owns features end-to-end (backend-leaning generalists welcome)
- Mentor / bar-raiser able to establish engineering best practices
- 8–15 yrs full-stack product engineering, building AI/LLM features
- Zero-to-one, customer-facing product background (not deep infra)
- Recent (1–2 yrs) hands-on shipping of LLM features / AI agents in production
Nice-to-have
- Mix of startup (seed–Series B, founding/early hire) and larger-company experience
- CS degree or equivalent
- Production AI evals / LLM observability (LangSmith, Braintrust, W multi-step agentic pipelines
- Genuine interest in bio, life sciences, or healthcare
Compensation & logistics
- Base salary: $210K–$260K, flexible for exceptional candidates
- Equity: 1–1.5%
- Full-time, hybrid: 3 days/week in-office (Mon, Tue, Thu), Financial District, San Francisco
- Visa: open to transfers (e.g., OPT, H-1B transfers); no new sponsorships
- Interview process: 3 steps — 30-min intro call, virtual system design interview, final on-site (technical + behavioral + team lunch)
$163k - $204k
...process. About the Team: We’re a small group of talented engineers, designers, data scientists, and product managers working to... ...Operations, and other cross-functional teams. Support the software platform that powers multiple 1st and 3rd party products and serves...SuggestedFull timeWork at officeLocal areaRemote work2 days per week3 days per weekGusto
San Francisco, CA1 day ago- ...this role, you will build the product that gets stuff built. You'll work closely with engineers, designers, and end-users to accelerate our product development. As a staff-level software engineer at Pulley, you will: Own problem areas, not just features—define the...SuggestedFull time
Pulley
San Francisco, CA1 day ago - ...API docs? Build agents that write, test, and deploy their own software packages? Anthropic is defining frontier AI. Ode is the team... ...and Dubai. The Role This role is designed for former engineering leaders (IC or EM) or founders who are comfortable owning end-...SuggestedFull timeRemote work
Ode With Anthropic
San Francisco, CA1 day ago - ...time, with the right message, through the right channel. As a Staff Engineer, you will lead the technical architecture of our unified... ...practices for CI/CD, automated testing, and monitoring for both software services and ML model performance in production. Mentorship...SuggestedFull timeInternshipWork at officeLocal areaImmediate startRemote workWorldwide3 days per week
Hinge Health, Inc.
San Francisco, CA1 day ago - ...’re a team of AI researchers, designers, growth experts, and engineers rethinking human-computer interaction from the ground up. We... ...firms and other well-known angels. About the Role As a Staff Software Engineer at Wispr, you’ll play a crucial role in building the...SuggestedFull time
Wispr Flow
San Francisco, CA1 day ago $241k - $284k
...ensuring web reliability and performance at scale. As a Staff Frontend Engineer on the App Platform team, you will play a leading technical... ...AI-powered tooling and practices into how we build and ship software. Our mission is to provide the foundation that helps every...Full timeWork at officeHome officeFlexible hours3 days per weekGlossgenius
San Francisco, CA1 day ago- ...Lunar is a stealth technology company building a new type of software platform for health systems. We are on a mission to... ..., ICUs, and Operating Rooms. We are looking for a Staff Product Engineer who's excited to tackle some of the hardest technical problems...Full time
Lunar, Llc
San Francisco, CA1 day ago - ...increase the speed and capacity of buildout, starting with data centers. About the Role At Watney, full stack engineers own our software ecosystem end-to-end, meaning you will regularly cross the boundary between high-throughput backend infrastructure, enterprise...Full time
Watney
San Francisco, CA1 day ago $220k - $250k
...team that believes in each other, come build with us at Crusoe. About the Role: We are actively seeking an exceptional Staff Software Engineer for our cloud software team who will contribute to the operations of our cutting-edge infrastructure. Your expertise will be...Full timeTemporary workCrusoe
San Francisco, CA1 day ago$200k - $250k
...customer. Kodiak is also leveraging its commercial self-driving software to develop, test and deploy autonomous capabilities for the U.S. Department of Defense. Kodiak is recruiting a Staff Software Engineer to join our Planning team and advance the Kodiak Driver’s...Full timeTemporary workWork at officeVisa sponsorshipFlexible hoursKodiak
San Francisco, CA1 day ago$200k - $225k
...Staff Software Engineer - Sensing (SF Bay Area) San Francisco Bay Area Job Title: Staff Software Engineer Location: SF Bay Area About Canopy At Canopy, we build technology that helps make healthcare environments safer for the people delivering care...Full timeCanopyworks
San Francisco, CA1 day ago$300 per month
...build with us at Crusoe. Crusoe’s Data Center Infrastructure Engineering (DCIE) team is fundamental to our mission of providing AI... ...About the Role: We are seeking a highly skilled and motivated Software Engineer to join Crusoe’s Data Center Infrastructure...Full timeTemporary workCrusoe
San Francisco, CA1 day ago- ...About the role Hinge Health is looking for a Staff Software Engineer to join our Device Software team inside Hardware R&D. This role is centered on the software systems behind a connected medical device experience, including device-control flows, mobile and backend integrations...Full timeLocal areaWorldwide
Hinge Health, Inc.
San Francisco, CA1 day ago - ...done. The Role We are seeking a skilled and motivated engineer with a strong interest in and background in front-end web development... ...prolifically with AI assistance and the mature judgment of a staff engineer. Enjoy a fast moving, dynamic startup environment....Full timeFlexible hours
Parkade
San Francisco, CA1 day ago $250k
...About Us XOXO is a research lab building the interface of intelligence for everyday life. We're a stealth team of hardcore engineers, designers, and researchers discovering solutions to novel problems impacting life outside work. With a recent breakthrough across...Full timeWork at officeXoxo Ai
San Francisco, CA1 day ago$224k - $264k
...customer satisfaction, across a complex, regulated domain. As a Staff Engineer in this organization, you'll operate across several product... ...field, or equivalent practical experience ~10+ years of software development experience and 3+ years experience in a project...Full timeWork at officeLocal areaRemote workRelocationFlexible hours3 days per weekCheckr
San Francisco, CA1 day ago$2,000 per month
...pathologically unfair at worst. Our mission is to reimagine the world of data with you. About The Role As a Principal/Staff Software Engineer , you will help build out the next generation data platform to support decentralized analytical and ML workloads, which...Full timeNextdata
San Francisco, CA1 day ago$240k - $270k
...platform on the modern data architecture. Hence, we are growing the engineering team and looking for engineers who are excited to solve... ...and workflows use cases on top of modern warehouses Build software using the latest developer tools and using programming languages...Full timeWork at officeFlexible hoursSigma Computing
San Francisco, CA1 day ago$320k - $405k
...Our team is a quickly growing group of committed researchers, engineers, policy experts, and business leaders working together to build... ...position Location-based hybrid policy: Currently, we expect all staff to be in one of our offices at least 25% of the time. However,...Full timeWork at officeVisa sponsorshipFlexible hoursAnthropic
San Francisco, CA1 day ago- ...customers. This role sits at the intersection of product and engineering– you'll own features end-to-end, from understanding user problems... ...engineering best practices Qualifications ~4+ years of software engineering experience, with at least 1-2 years building AI/ML...Full time
Emergence Capital Partners
San Francisco, CA1 day ago - ...2 days per week in office) About our Engineering Teams We're hiring across multiple... ...set and where you want to grow. Our software development is AI-centric and requires demonstrated... ...Terraform What You Will Do As a Staff Software Engineer, you are the archetype...Full timeBank staffWork at officeNight shift2 days per week
Sydecar
San Francisco, CA1 day ago $200k - $230k
...Staff Software Engineer About Cambly: Our mission is to bring high-quality English education to every English learner in the world at the touch of a button. Think of us as the Airbnb that matches English students with English tutors. Come help us build the world's...Full timeWork experience placementWork at officeCambly Inc.
San Francisco, CA1 day ago- ...of infrastructure and product. On one side, it's real systems engineering: alerts, balances, and entitlement checks computed against actual... ...pain points into what we build About you: ~9+ years of software engineering experience, with a track record of owning products...Full timeWork at officeRemote workFlexible hours3 days per week
Orb
San Francisco, CA1 day ago $405k
...Our team is a quickly growing group of committed researchers, engineers, policy experts, and business leaders working together to... ...the Role Anthropic is seeking talented and experienced Staff+ Software Engineers to join our Continuous Integration (CI) team within...Full timeWork at officeVisa sponsorshipFlexible hoursAnthropic
San Francisco, CA1 day ago- ...Built by exited founders, YC & MIT alum , ex-Tesla, ex-Google engineers. Hypergrowth with stability: We went from initial idea to... ...Experience 4-7 years of experience (or equivalent) as a software engineer. We’re leveling this role to Pave’s “P4” level :...Full timeLive in
Neon Health
San Francisco, CA1 day ago - ...example, helping others reach their true potential and driving engineering best practices. Optimize for Value: Leverage strong... ...you'll bring: Seasoned Engineering Expertise: 7+ years of software engineering experience with a track record of delivering significant...Full time
Casca
San Francisco, CA1 day ago - ...in our recruiting process here . The Trends & Insights Engineering team builds the products that turn Pinterest's unique signal... ...shopping for into actionable intelligence for advertisers. As a Staff Software Engineer on this team, you'll lead the technical evolution...Full timeWork at officeRemote workRelocationRelocation packageDay shift
Pinterest
San Francisco, CA1 day ago - ...advertisers and partners. Role Summary We’re seeking a Staff Engineer to lead the architecture and technical direction of the measurement... ...equivalent practical experience. ~8+ years of professional software engineering experience, with a focus on data‑intensive...Full timeWork at officeRemote workRelocationRelocation package
Pinterest
San Francisco, CA1 day ago $231k - $340k
...outcomes. We stay close to our customers — from leadership to engineers — and work together to solve real problems with urgency and care... ...to ship ambitious AI features rapidly and safely. As a Software Engineer on the Developer Experience team, you will be responsible...Full timeHarvey
San Francisco, CA1 day ago$320k - $405k
...growing group of committed researchers, engineers, policy experts, and business leaders working... ...reliably, and with confidence. As a Software Engineer on this team, you'll be hands-... ...policy: Currently, we expect all staff to be in one of our offices at least 25%...Full timeWork at officeVisa sponsorshipFlexible hoursAnthropic
San Francisco, CA1 day ago
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Staff Software Engineer. Be the first to apply!
- software technology San Francisco, CA
- remote software sales San Francisco, CA
- embedded software San Francisco, CA
- software intern San Francisco, CA
- software support San Francisco, CA
- ultimate software San Francisco, CA
- software engineer - cloud services San Francisco, CA
- entry level software sales San Francisco, CA
- software trainer San Francisco, CA
- software San Francisco, CA