Senior Scientist, Target Discovery & Biology - Functional Genomics
$123.05k - $166.48kAmgen Inc
Career Category Scientific Job Description
Join Amgen’s Mission of Serving Patients
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Senior Scientist, Target Discovery & Biology - Functional Genomics
What you will do
Let’s do this. Let’s change the world. In this vital role you will join the Target Discovery & Biology team in South San Francisco. This role will leverage functional genomics in disease-relevant systems, including complex biological models from in vitro to in vivo , to advance target discovery and validation across Amgen’s therapeutic areas.
Key Responsibilities
- Leverage functional genomics approaches across therapeutic areas to discover novel targets and address key biological questions
- Lead, support and execute projects from inception through target identification, validation and mechanism-of-action studies
- Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a researcher with these qualifications.
Basic Qualifications:
Doctorate degree PhD
OR
PharmD OR
MD [and relevant post-doc scientific experience in Target Discovery & Biology]
OR
Master’s degree and 3 years of relevant scientific experience in Target Discovery & Biology
OR
Bachelor’s degree and 5 years of relevant scientific experience in Target Discovery & Biology
Preferred Qualifications:
- Strong experience in molecular biology and cell engineering. Experience in complex and co-culture in vitro models is a major plus
- Experience in executing large scale, complex, and/or in vivo genetic screens (particularly CRISPR-based) and follow up validation studies. Track record of pushing the envelope on scale and technical feasibility is highly desirable
- Familiarity with data-driven discovery approaches, including integration of genetic or multi-omics insights
- Excellent organizational and communication skills, with the ability to drive cross-site collaboration in a matrixed research environment
- Additional experience relevant to applying functional genomics approaches to new target discovery across diverse indications
- Track record of scientific productivity and innovation as demonstrated through career experiences, project outcomes and/or publications
- Track record of taking on new areas of research and biology with successful outcomes
What you can expect from us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.
Apply now and make a lasting impact with the Amgen team.
careers.amgen.com
In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadline
Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
Sponsorship
Sponsorship for this role is not guaranteed.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.Salary Range
123,052.80USD -166,483.20 USD$123.05k - $166.48k
...part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Scientist, Target Discovery & Biology - Functional Genomics What you will do Let’s do this. Let’s change the world. In this vital role you will join the...TargetSeniorFull timeFlexible hours$136k - $170k
...AI to transform drug discovery and development. The... ...-to-drug molecular targets. It is also developing... ...models for biology and disease to enable... ...and highly motivated Senior Scientist to architect and lead... ...through high-throughput functional genomics. You will lead strategic...TargetSeniorFlexible hours- Genentech is seeking a Scientist 3 to advance target discovery through cutting-edge genomics and molecular engineering. You will design and apply functional genomics read-outs, model systems, and imaging... ..., genomics, and computational biology, and leadership of research...TargetSenior
$131.03k - $177.27k
...transforming your career. Senior Scientist - Experimental Protein Design for Target Discovery What you will do Let's do... ...molecules to interrogate novel biology and providing tool reagents... ...developing cellular-based assays for functional characterization....TargetSeniorFull timeFlexible hours$136k - $161k
...while transforming your career. Senior Scientist - Functional Genomics What you will do Let’s do... ...profiling technologies to advance target discovery, validation, and progression across... ...area, human genetics, computational biology, and therapeutic development teams...TargetSeniorRemote workFlexible hours- ...state changes into clear biological conclusions that drive... ...heart of Gordian's discovery efforts, and the company... ...prioritize the best targets and interventions.The... ...with clinically relevant genomic resources to address... ...developments in single-cell and functional genomics, human...TargetSeniorAgency workDay shift
$103.4k - $192k
...Department of Cell and Tissue Genomics (CTG) at Genentech is... ...and innovative Scientist 3 to leverage cutting... ...strategies for target discovery and next-generation therapeutic... ...technologies, biologically relevant models, and... ...of-the-art genomics, functional, and imaging read-outs...TargetFull timeLocal areaRelocation package- Scientist/Senior Scientist (Genomic Analysis) About this position About Preventive... ...safety/off‑target profiling. The role... ...custom references). Biological interpretation:... ...‑to‑end off‑target discovery/validation for gene... ...priorities, and cross‑functional collaboration). Share...TargetSenior
$200k - $250k
The opportunity As a full-time Senior Scientist on the Machine Learning team, you... ...platform for RNA structure prediction, target identification, and early drug discovery. You will co-lead the... ...Materials Science, Computational Biology, or related field. 5+ years of experience...TargetSeniorFull time- ...Francisco Bay Area is seeking a Senior Scientist to architect and lead in vivo... ...You will push high-throughput functional genomics at the intersection of mouse biology, data science, AI/ML, and translational... ...computational biology and drug discovery teams to translate data into...Senior
$124k - $155k
...AI to transform drug discovery and development. The... ...-to-drug molecular targets. It is also developing... ...models for biology and disease to enable... ...About the Role As a Scientist II on Xaira's Genomics Core team within the... ...partner closely with Functional Genomics, Disease Biology...TargetFlexible hours- Senior Scientist - Degrader Antibody Conjugate Cellular Nurix... ...company focused on the discovery, development, and commercialization of targeted protein degradation... ...closely with discovery biology, conjugation chemistry... ...influence a matrixed, cross‑functional organization,...TargetSenior
$150k - $170k
...leveraging AI to transform drug discovery and development. The company is... ...hard‑to‑drug molecular targets. It is also developing foundation models for biology and disease to enable better target... ...with an emphasis on optimizing functional properties and developability....TargetSeniorFlexible hours$147.8k - $274.4k
...We seek a highly motivated Senior ML Scientist to join the Foundation... ...) within the AIBT (AI for Biology & Translation) department... ...‑world impact in drug and target discovery, with a focus on large‑scale... ...interdisciplinary and cross‑functional teams across gRED and Roche...TargetSeniorLocal areaRelocation package- ...transforming drug discovery and development. Roche... ...AI) to assist our scientists in both pRED and... ...Opportunity AI Biology & Translation (AIBT... ...biological data to advance target discovery, disease... ...We are seeking a Senior Machine Learning... ..., including genomics, transcriptomics,...TargetSeniorLocal areaWorldwideRelocation package
$251k - $295k
...oncology company developing novel targeted therapies for patients with... ...Opportunity We are seeking a Senior Machine Learning Scientist to help accelerate drug discovery through advanced analytics and... ...that transform complex biological and chemical datasets into actionable...TargetSeniorFull timeLocal area- ...platform enables Fulcrum scientists to explore target and therapeutic... ...Reporting to the VP, Biology, you will execute... ...challenge studies, and functional cellular readouts of... ...-omic biomarker discovery and systems-level target... ...into Scientist II / Senior Scientist roles as...TargetSeniorFull timeContract workTemporary workPart timeRelocationAfternoon shift
$125k - $180k
...Clinical Development Scientist/Senior Clinical Development... ...penetrant NLRP3 inhibitor targeting cardiometabolic and... ...is complemented by discovery-stage programs across... ...motivated to translate biology into impactful... ...Scientist lead on cross‑functional study teams for selected...TargetSeniorInterim roleLocal areaRemote work- ...at South San Francisco, CA, is seeking a Scientist 3 in CVRM Discovery/Research Biology to investigate novel pathways and targets in cardiovascular, renal, and metabolic diseases... ..., and presenting findings across cross-functional teams and external venues, with relocation...TargetRelocation package
- Genentech is seeking a Scientist 3 to advance target discovery using cutting-edge genomics and molecular engineering in immune-mediated diseases. The role integrates technology development with disease biology, collaborating across immunology, genomics, AI/ML, and cell...TargetRelocation package
- Genentech is seeking a Scientist 3 to execute cutting-edge single-cell and functional genomic techniques to study cancer biology. You'll perform high-throughput screens, deploy single-... ...data to reveal molecular mechanisms and targets for therapy. The role requires a PhD in...Senior
$202.8k - $376.6k
...transforming drug discovery and... ...to assist our scientists in both pRED and... ...OpportunityThe AI Biology & Translation... ...program focused on Genomics AI and... ...biology.As a Senior Principal Scientist... ...insights for target discovery and... ...epigenomics, functional genomics, regulatory...TargetSeniorFull timeLocal areaWorldwideRelocation package$103.4k - $192k
Scientist 3, CVRM Discovery / Research Biology Aug 12, 2026 $103,400 - $192,000/year A healthier future. It’s what... ...3 to investigate novel pathways, targets, and therapeutic development in cardiovascular... ...while collaborating with cross-functional teams of scientists and clinicians...TargetLocal areaRelocation package$168.1k - $312.3k
...transforming drug discovery and development.... ...AI) to assist our scientists in both pRED and... ...optimization, and functional modeling to real... ...looking for a talented Senior Scientist who... ...in Computational Biology, Biophysics,... ...include the first targeted antibody for cancer...SeniorLocal areaWorldwideRelocation package$167.4k - $310.8k
...are transforming drug discovery and development. Roche... ...Intelligence (AI) to assist our scientists in both pRED and gRED... ...discovery—from target assessment and design... ...a highly motivated Senior Machine Learning Scientist... ...ML models to biology and large molecule drug...TargetSeniorFull timeLocal areaWorldwideRelocation packageShift work- Preventive is seeking a Scientist/Senior Scientist to lead genomic analysis across wet-lab experiments and computational pipelines. You will design, execute... ...emphasis on epigenetic characterization and safety/off-target profiling. Responsibilities include developing...TargetSenior
$71.25k - $187k
...waiting. We unite caring with discovery to help make life better for... ...with active programs in T cell biology, cellular reprogramming, CAR-... ...isolation, culture, and functional characterization of T cells and... ...cellular assays to interrogate target biology, including panel...TargetSeniorFlexible hours$183k - $238k
...aspects of in-vitro biology are at the heart... ...machine learning scientists, support the... ...part of a cross-functional team of life scientists... ...therapeutic targets and develop drugs... ...transcriptomics, functional genomics, genetics, human... ...is a drug discovery and development company...TargetSeniorHome officeFlexible hours$103.4k - $192k
...PositionThe OpportunityDepartment of Immunology Discovery at Genentech is seeking a highly talented, driven and motivated Scientist 3 for the Kim lab to investigate novel pathways, biologics and potential therapeutic targets to treat autoimmune diseases. This Scientist 3...TargetFull timeLocal area$100.4k - $186.4k
...encompasses biomarker discovery, personalized... ..., advance novel target understanding, and... ...highly motivated Scientist 3 to join... ...discovery and disease biology insights. This role... ...Collaborate cross-functionally with Clinical... ...Immunology, Functional Genomics, or a closely...TargetFull timeLocal areaRelocation package
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Senior Scientist, Target Discovery & Biology - Functional Genomics. Be the first to apply!
- scientist ii South San Francisco, CA
- machine learning scientist South San Francisco, CA
- scientist South San Francisco, CA
- quality control scientist South San Francisco, CA
- qc scientist South San Francisco, CA
- regulatory scientist South San Francisco, CA
- research scientist - biology South San Francisco, CA
- scientist antibody discovery South San Francisco, CA
- applied scientist South San Francisco, CA
- associate scientist South San Francisco, CA


