Postdoctoral Fellow - Cell Therapy Institute

A postdoctoral fellow position is available in the department of Cell Therapy Institute. The primary purpose of the Postdoctoral Fellow is to assist the Principal Investigator and other Faculty members with scientific research projects within the Institute for Cell Therapy Discovery and Innovation. The primary activity of this position is with a team of cancer immunotherapy lab researchers.

We seek a postdoc position focused on developing lipid nanoparticle for in vivo delivery of mRNA for cancer and other human disease. We are a fast-paced and collaborative team working on CAR NK/T based cancer immunotherapy in clinical trials. This position will primarily lead to the use of proprietary LNP formulation and conjugation technology to deliver and target different cell types specifically in human patients. You will seal the gap between LNP-mRNA-based targeting and our CAR NK immunotherapy. The applicants should have a deep understanding of lipid chemistry, hands-on laboratory work with lipid nanoparticle, lipid toxicity, LNP formulation, characterization, functionality assay in vitro and in vivo.

Cell Therapy is expanding with numerous cell projects being developed by academic centers and industry. The development of a cell therapy product is complex and requires integration of multiple disciplines with a common purpose. We have proven our capacity for leadership in the field of cell therapy by developing novel therapies such as viral CTLs and a CAR NK program. We are currently world leaders in the use of CAR-NK to treat cancer

All duties and responsibilities are carried out in compliance with institutional policies, ethical research standards, and applicable federal and state regulations.

LEARNING OBJECTIVES

• Formulation and conjugation of lipid nanoparticles

• In vitro screening of delivery systems

• work closely with other members in the lab on cell culture and mouse studies.

• Maintain detailed records of analytical data

• Interface directly with other functional teams

• Work independently and collaboratively to drive design, functional screening, development and production of novel tLNP formulations for targeted in vivo delivery

ELIGIBILITY REQUIREMENTS

• PhD degree in chemistry, biochemistry, or bioengineering with experience on LNP design and delivery.

• Demonstrated ability with respect to successful designed, formulation, and test for LNP functionality and toxicity.

POSITION INFORMATION

Offsite work arrangements are subject to approval and may be modified or revoked at any time based on business needs, performance considerations, or regulatory requirements.

This position may be responsible for maintaining the security and integrity of critical infrastructure, as defined in Section 113.001(2) of the Texas Business and Commerce Code and therefore may require routine reviews and screening. The ability to satisfy and maintain all requirements necessary to ensure the continued security and integrity of such infrastructure is a condition of hire and continued employment.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.