Director, Portfolio Governance

The Director, Portfolio Governance is a strategic leadership role accountable for designing, enabling, and continuously improving the Development governance framework that drives high-quality, timely decision-making across the development portfolio. This role embeds decision excellence, clarity of decision rights, and disciplined execution across the governance forums.
This leader ensures decisions are made at the right level, with the right information, at the right time—enabling portfolio tradeoff decisions, reducing cycle time, and improving decision quality and durability.

This role is a hands-on contributor and people manager responsible to build relationships at all levels of the organization in order to solicit and action stakeholder input regarding the governance framework. This role will navigate the fast-paced and agile environment of Regeneron in a collaborative and innovative manner.

***Please note this role is an onsite opportunity and is not eligible remote.

A typical day in this role looks like:

• Own and continuously evolve the governance framework to enable effective, scalable decision-making across the portfolio.
• Establish and enforce decision quality and readiness standards, including clear articulation of options, trade-offs, risks, and recommendations.
• Where required, facilitate governance forums to ensure structured, decision-focused discussions and clear, actionable outcomes.
• Define and manage governance performance metrics (e.g., decision cycle time, right-first-time decisions, deferrals, forum utilization) to assess effectiveness.
• Translate governance metrics and feedback into actionable insights, driving a closed-loop continuous improvement model.
• Synthesize governance outputs into portfolio-level insights, identifying cross-program risks, recurring issues, and systemic bottlenecks.
• Establish and maintain centralized decision documentation and knowledge management practices to ensure transparency and traceability.
• Oversee governance intake, prioritization, and scheduling to ensure alignment to strategic importance, while advancing efficient, scalable processes and leveraging technology to streamline execution.
• Drive cross-forum integration to streamline escalation pathways, eliminate duplication, and improve decision flow.
• Partner closely with senior leaders, governance chairs, and stakeholders to align priorities and reinforce governance expectations.
• Implement governance quality and experience measurement, incorporating multi-directional feedback from teams, executives, and chairs to improve effectiveness.
• Coach and develop team members ensuring that the organizational strategy delivers the skills, capabilities and processes that enable portfolio delivery are present in his/her team

This role may be for you if you have:

• Deep understanding of drug development lifecycle and portfolio management.
• Proven experience designing governance frameworks, operating models, or decision-making processes.
• Strong analytical skills with ability to translate data into insights and actions.
• Experience with process improvement methodologies (Lean, Six Sigma) preferred.
• Exceptional executive communication and facilitation skills.
• Demonstrated ability to influence senior leadership and drive change in matrixed environments.
• Strong stakeholder management and cross-functional leadership capabilities.
• Demonstrate experience leading and developing high-performance teams, including direct people management.
• Experience leveraging technology and digital solutions to enable scalable processes, improve efficiency and enhance decision-making (e.g. dashboards, workflow tools, analytics platforms).
• Ability to travel (<10%).

In order to be considered qualified for the this role a minimum of a Bachelor's degree and Minimum 12+ years of experience in biotechnology, pharmaceutical development, or consulting.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit For other countries’ specific benefits, please speak to your recruiter.
Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regeneron’s roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regeneron’s on-site policy and expectations for your role and your location.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)