Scientist II

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

Job Description

We are seeking a highly motivated Scientist to join Discovery Immunology’s Nonhuman Primate (NHP) In Vivo Pharmacology team. As part of that team, this position will drive the development and deployment of NHP in vitro and in vivo models to support AbbVie’s Immunology drug discovery efforts. This is a hands-on and lab-based role requiring significant cell biology and ex vivo expertise. The ideal candidate will have extensive experience with primary cell cultures and in vitro cell-based assays in the context of autoimmune disease.

Key Responsibilities:

• Routine culture and maintenance of immortalized and primary cell cultures, especially of NHP and human origin.
• Isolation of primary human cells from various sources including tissue and whole blood.
• Work with a Principal Scientist to develop flow cytometry panels for immunophenotyping
• Design, perform, and interpret in vitro experiments to support drug discovery and development activities with both human and NHP primary immune cells.
• Conduct experiments with a high level of independence and initiative and performing tasks with minimal direct supervision for routine methods.
• Independently schedule and prioritize workload to manage several tasks simultaneously
• Maintain detailed and timely electronic documentation to ensure adherence to departmental procedures and contribute to final reports as needed.
• Interact with other scientists within a matrixed environment including to identify / utilize resources outside of own group and presenting findings to audiences with diverse backgrounds (e.g., immunologists, cell biologists, pathologists, bioengineers).

Qualifications

• Bachelor’s Degree at least 5 years of experience, or Master’s Degree with at least two years of experience.
• Experience working with human tissue samples and with isolating and characterizing cells such as epithelial, fibroblast, endothelial, and/or immunological (B cells, T cells, monocytes) by methods such as tissue digestion and dissociation. Extensive experience with primary cell cultures and in vitro cell based assays.
• Demonstrated proficiency in cell and molecular biological assays such as qPCR analysis, multicolor flow cytometry, FACS, ELISA/Luminex/MSD, cell proliferation/viability assays, cytotoxicity, and in vitro cell stimulation assays
• Strong written/oral communication and presentation skills are important. Experience with electronic lab notebooks is preferred.
• Experience with statistical analysis and graphing software (Excel, FlowJo, GraphPad Prism)
• Ability to build relationships and work collaboratively with cross-functional teams in a highly matrixed organization.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this roleat the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on manyfactors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount isearned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that areallocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolutediscretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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