CNC Programmer

Repligen is seeking a highly skilled and detail-oriented CNC Programmer/Machinist with a minimum of five (5) years of hands-on experience in programming, setting up, and operating 3-, 4-, and 5-axis CNC machines within a fast-paced production environment. This role is responsible for overseeing the full machining lifecycle-from initial programming and setup through final production and quality validation.

The ideal candidate will demonstrate strong proficiency in Mastercam, including the ability to create, modify, and optimize toolpaths to maximize efficiency, precision, and repeatability. Responsibilities include machine and fixture setup, tool selection, prove-outs, and executing production runs that consistently meet tight tolerance and quality requirements.

In addition to core machining responsibilities, this role involves working with 3D models, supporting fixture design and process improvements, conducting in-process inspections, and performing secondary finishing operations such as polishing and metal finishing. The successful candidate will collaborate closely with Engineering and the Shop Supervisor to identify opportunities for continuous improvement, streamline workflows, and enhance overall production performance.

"This role is expected to model our Leadership Behaviors-Integrity & Compliance, Customer Focus, Collaboration, Courage, Team Empowerment, and Accountability & Results-in all aspects of work."
Primary Duties and Responsibilities

• Program, set up, and operate 3-, 4-, and 5-axis CNC machines in a production environment
• Develop, refine, and optimize tool paths to improve cycle times, quality, and repeatability
• Perform complete machine setups, including tooling selection, fixture alignment, and initial prove-outs
• Run production parts while ensuring compliance with tight tolerances and customer specifications
• Conduct in-process inspections using appropriate measuring tools and make necessary adjustments to maintain quality standards
• Perform secondary operations such as polishing, sanding, and finishing as required
• Interpret technical drawings, blueprints, and 3D models to support accurate machining
• Collaborate with Engineering and Shop Leadership to improve processes, reduce waste, and increase efficiency

Education and/or Work Experience Requirements:

• 5-6 years of CNC programming experience in a precision environment
• Proven expertise in CNC machining and programming in a high-volume setting
• Minimum 5 years of Mastercam programming experience (required)
• Proficiency in CAM software (Mastercam) and CAD software (SolidWorks required, Esprit a plus)
• Strong experience with 3-, 4-, and 5-axis CNC machines
• Experience supporting aerospace OEMs (e.g., Boeing) or Tier 1 suppliers highly preferred
• Ability to read and interpret engineering drawings, blueprints, CAD models, and GD&T
• Strong attention to detail, accuracy, and consistency
• Solid problem-solving skills with a continuous improvement mindset
• Effective communication skills (verbal and written)
• Strong understanding of workplace safety practices and procedures
• High school diploma or equivalent; technical training preferred
• Willingness to work overtime and weekends as needed

Physical Requirements:

• Regularly required to stand; walk; use hands to finger, handle, or feel and talk or hear.
• Frequently required to sit; reach with hands and arms and stoop, kneel, crouch, or crawl.
• Must regularly lift and /or move up to 25 pounds, frequently lift and/or move up to 10 pounds and occasionally lift and/or move up to 50 pounds.
• Specific vision abilities required by this job include Peripheral vision and Depth perception.
• Regularly exposed to work near moving mechanical parts and vibration
• Occasionally exposed to fumes, toxic or caustic chemicals or airborne particles
• Primarily indoor cleanroom work with usually loud noise level
• Occasional work outside of the cleanroom

Work Environment

This position is generally indoors, in a well-lighted, heated, fan-cooled production environment. All work is primarily standing (90 + % of the shift) with the exception of breaks, lunch periods, and the occasional meeting. Polishing and post machining finishing activities are regular and frequent, and these require a high degree of sanding, heavy polishing, and metal finishing that are combinations of fine motor activities and coarser work. The incumbent is required to regularly lift, carry, bend, move, and manage materials weighing up to 45 pounds each on a regular basis.


Our mission is to inspire advances in bioprocessing as a trusted partner in the production of biologic drugs that improve human health worldwide. Focused on cost and process efficiencies, we deliver innovative technologies and solutions that help set new standards in bioprocessing. The estimated hourly rate/salary range for this role, based in the United States of America is $33.00-$45.00. Compensation decisions are dependent on several factors including, but not limited to an individual's qualifications, location, internal equity, and alignment with market data. Additionally, employees are eligible to participate in one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits such as paid time off, health/dental/vision, retirement benefits and flexible spending accounts. All compensation and benefits information will be confirmed in writing at the time of offer.