Associate Scientist II, Oncology

OverviewThe Oncology group at Alnylam is seeking a highly motivated Associate Scientist II to join our team. As a focused, interdisciplinary team, we are seeking to bring the power of RNA therapeutics to the fight against cancer. The successful candidate will be responsible for supporting delivery research efforts to advance Alnylam’s RNA platform across multiple cancer indications. The ideal candidate will have a background in immuno-oncology and/or cell and gene therapy and molecular and immune-cell based techniques including LNP-mediated transfection, electroporation and multi-color flow cytometry. The role requires the ability to learn new techniques, the capacity to multi-task, and the willingness to collaborate with multiple interdisciplinary teams in a fast-paced environment.This position is onsite and will be primarily located in Cambridge, MA.Key ResponsibilitiesDesign, optimize, and execute cell and molecular based experiments to evaluate the activity of developmental RNA candidates in relevant in vitro oncology models.Execute immunology-focused cell culture studies and functional assays to support discovery and translational research programs.Perform and optimize LNP-mediated and electroporation-based transfection methods in immune cell systems to enable experimental objectives.Conduct, analyze, and interpret multicolor flow cytometry assays using 10 to 14 color panels for immune profiling and functional characterization.Perform downstream processing and analysis from tissue samples and ex vivo models to support evaluation of target engagement, mechanism of action, and biomarker analysis of RNA therapeutics.Analyze, interpret, and present research findings within a multidisciplinary Oncology team and to the wider organization to facilitate cross-functional collaboration.Excellent documentation practices in maintaining electronic lab notebook entries, protocols, data summaries, and technical reports.QualificationsBS in Biology, Immunology, Molecular Biology, Bioengineering, or related field with 2-3 years or MS with 1+ years of experience in industry or academic lab setting.Hands-on experience in the execution of primary immune cell and tumor-immune cell co-culture assays for the characterization of immunomodulatory therapeutics.Experience working with nucleic acid-based approaches (such as RNAi, CRISPR, mRNA, plasmid DNA).Proficiency in molecular and cellular techniques including RT-qPCR, immunofluorescence, multi-color flow cytometry, Incucyte, and ELISA.Experience in accelerating discovery with implementation of high-throughput screening methods is highly desirable.This is an on-site lab-based role; candidates must be comfortable with extensive bench work and collaborative team science.Ability to optimize and perform experiments and summarize results with limited guidance.Must be a team player with good interpersonal skills, open to new tasks and challenges in a fast-paced environment.#LI-JR1U.S. Pay Range$67,600.00 - $101,400.00The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: AlnylamWe are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. #J-18808-Ljbffr Alnylam Switzerland GmbH