Principal Software Engineer, ePrescribing
$177.5k - $222.5kPrescryptive Health, Inc.
About the Role As Principal Software Engineer, ePrescribing, you own the architecture, reliability, and evolution of Prescryptive’s ePrescribing platform—the technical backbone that ensures prescriptions move accurately, securely, and at scale across a complex healthcare ecosystem. Key Accountabilities Domain ownership: Set technical direction and manage system health for ePrescribing across the platform. Architecture & scale: Design systems that support interoperability, multi-version standards, and growth across customers and partners. Standards strategy: Lead adoption and evolution of NCPDP standards, including version transitions and long-term compatibility. Production leadership: Establish patterns for rapid diagnosis and resolution of issues in live environments. Cross‑functional influence: Drive alignment across Engineering, Operations, Customer Care, and external partners. Primary Responsibilities Define and evolve the architecture for ePrescribing systems, ensuring scalability, reliability, and interoperability. Lead implementation of NCPDP SCRIPT standards, including multi‑version support and translation services (e.g., 2017 2023). Design and optimize XML‑based message processing, including schema strategy, transformation, and validation. Establish patterns and tooling for certification, validation, and onboarding of new partners and message types. Own complex production issues end‑to‑end, setting the standard for real‑time troubleshooting and resolution. Partner with Operations and Customer Care to improve system transparency and reduce issue resolution time. Integrate with external networks (e.g., Surescripts, Change Healthcare) and ensure resilient partner connectivity. Identify and address systemic gaps, reducing single points of failure and improving long‑term maintainability. Mentor engineers and elevate team capability in healthcare interoperability and system design. Required Skills, Abilities, and Education Bachelor’s degree in engineering, computer science, or related field. Deep, hands‑on expertise in NCPDP ePrescribing (SCRIPT) standards. Proven track record designing and operating distributed, message‑driven systems. Strong command of XML and schema‑driven integrations. Experience owning end‑to‑end ePrescribing workflows and interoperability across systems. Background working with: EHR/EMR systems (e.g., Epic, Cerner). Pharmacy Management Systems (PMS). Retail and/or long‑term care pharmacy workflows. ePrescribing networks/intermediaries (e.g., Surescripts, Change Healthcare). Demonstrated ability to operate in high‑urgency, production‑driven environments. Strong communication skills across technical and non‑technical stakeholders. Must have permission to work in the U.S. on a permanent basis. Preferred Skills, Abilities, and Education Experience designing multi‑version interoperability and translation layers. Exposure to long‑term care workflows. Experience in regulated healthcare environments. Track record of leading system evolution in scaling or early‑stage environments. What We Have to Offer The opportunity to grow alongside an early‑stage company shaking up a big, old‑fashioned industry. Flexible time off, including 12 paid holidays. 401(k) match plus 100% employer paid medical, dental, and vision premiums. Company contribution to Health Savings Account. Stock options. Prescryptive is committed to fair pay practices. The projected annual salary for this position is $177,500 to $222,500. Prescryptive is an Equal Opportunity Employer. Prescryptive does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, non‑disqualifying physical or mental disability, national origin, veteran status, or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need. #J-18808-Ljbffr
$177.5k - $222.5k
...Prescryptive Health, Inc. is seeking a Principal Software Engineer in the United States to oversee the architecture and reliability of their ePrescribing platform. This role requires expertise in NCPDP ePrescribing standards and a strong background in designing distributed...SuggestedFlexible hours$220k - $300k
...Principal Software Engineer — AI & Distributed Systems Platform - $220,000 - $300,000 base salary A rapidly scaling AI-native platform operating in the legal and capital markets space is hiring a Principal Software Engineer to help architect the next generation of production...Suggested- ...people should have control over how their trucks look, feel, and represent them. About the Role We’re looking for a Principal Software Development Engineer - Frontend to help lead our software development in the electric vehicle space. You will focus on defining and...SuggestedPermanent employmentWork experience placement
$197.4k - $264.7k
...Principal Software Engineer Disney Entertainment and ESPN Product & Technology is a global organization of engineers, product developers, designers, technologists, data scientists, and more – all working to build and advance the technological backbone for Disney's media...SuggestedWork experience placement- ...About the Team OpenAI’s B2B Engineering team brings our most capable technology to the world through our developer platform and enterprise... ..., dependable products. About the Role We’re looking for a Principal Software Engineer to design and scale the systems that power our...Suggested
- ...Principal Software Engineer If you are looking for a game-changing career, working for one of the world's leading financial institutions, you've come to the right place. As a Principal Software Engineer at JPMorgan Chase within the Consumer & Community Bank supporting...
$200k - $250k
...Principal Software Engineer, Full-Stack AI Standard Template Labs is a stealth-mode, AI-native startup reimagining the future of IT Service and Configuration Management. Backed by leading investors, we're leveraging AI, graph-based architecture, and exceptional design...Local area- ...Senior Principal Software Engineer We're looking for a tech leader ready to take their career to new heights. Join the ranks of top talent at one of the world's most influential companies. As a Senior Principal Software Engineer at JPMorganChase within the CDAO AI...
$276k - $414k
...other services; and its AR glasses, Spectacles ( . Snap Engineering ( teams build fun and technically sophisticated products that... ...with privacy at the forefront. We're looking for a Principal Software Engineer to join Snap Inc! What you'll do: Design, implement...Temporary workLive inWork at officeLocal area$203k - $260k
...Principal Software Engineer Paramount Skydance Corp. is seeking a Principal Software Engineer to architect, build, and scale AI-driven tooling and engineering platforms that accelerate quality, automation, and developer productivity across the Global Quality Engineering...- ...Principal Software Engineer - Pay Group Engineering We're hiring seasoned engineers to join our teams that work on core platform capabilities, improving our existing systems for extensibility and scalability, and building the future of Gusto's Payroll and Tax systems...
$165.22k - $283.23k
...bring generative intelligence into the physical world. As a Principal Engineer, you will set the technical direction for systems that blend... ...Basic Qualifications ~10+ years of professional software development experience ~ Experience designing and scaling...Local areaImmediate start- ...To support rapid scaling, the full-time remote Principal Software Engineer will lead key technical decisions and implement significant software projects across frontend, backend, or full-stack domains, driving high-impact initiatives to enhance the product. Key responsibilities...Full timeRemote work
$200k - $240k
...Principal Software Engineer Boulder, Colorado or New York City, New York or Remote About Sovrn Every interesting company solves important problems for other people. Sovrn is a Software and Data business that helps Open Web businesses be and remain independent....Temporary workWork at officeRemote workFlexible hours$203k - $260k
...moments that matter - both for our audiences and our employees - and aim to leave a positive mark on culture. Job Title : Principal Software Engineer - AI Tooling & Quality Engineering Platforms Team : Global Quality Engineering (GQE) Location : New York City,...$276k - $414k
...other services; and its AR glasses, Spectacles ( . Snap Engineering ( teams build fun and technically sophisticated products that... ...with privacy at the forefront. We're looking for a Principal Software Engineer to join the Business Experience team at Snap. What...Temporary workLive inWork at officeLocal area$132k - $264k
...Position Summary... What you'll do... Role summary As a Principal Software Engineer (ML) , you will lead the design and development of production-grade AI systems that transform large-scale data into intelligent, deployable solutions. You will operate at the...Full timeTemporary workPart time$204k - $337k
...Principal Software Engineer The Builders Hub Team, part of the Mastercard Software Builders Experience program, owns and drives developer experience for the company. The team has a unique opportunity to create a unified internal developer portal supporting and helping...Full timePart timeFlexible hours$142.8k - $274.8k
...Do you enjoy solving problems, writing software, and working with customers? Do you want... ...join us! The Industry Solutions Engineering (ISE) team is a global engineering organization... ...platform. We are hiring a Principal Software Engineer with deep experience...Ongoing contractLocal areaVisa sponsorshipWork visaFlexible hours- ...responsible for creating, designing, deploying, and supporting applications, programs, and software solutions. May include research, new development, prototyping, modification, reuse, re-engineering, maintenance, or any other activities related to software products used...Remote workFlexible hours
$119.8k - $234.7k
...Overview About the Role ~ We'rebuildingAIfirst engineering systemsthat power growth at Microsoft - designing, shipping,... ...engineering environment What We're Looking For ~ Software engineering fundamentals with experience building, shipping,...Ongoing contractLocal area£80k - £110k per year
...00 - £110,000 Harrington Starr has partnered with a leading Global Payments Technology company who are seeking to hire a Principal Software Engineer to join their senior engineering leadership team. This is a rare opportunity to combine hands‑on development with strategic...Permanent employmentRemote workFlexible hours- ...Our offices are located in San Francisco, New York, Austin, Seattle, India, and the United Kingdom. About the Role As a Principal Software Engineer, you will design, architect, and deliver scalable, AI‑powered distributed systems that power Demandbase’s next‑generation...Temporary workFlexible hours
$210k - $240k
...We're building an autonomous infrastructure engineering agent: think Claude Code, but for your cloud. If you're excited about agentic AI... ...connection. About Pulumi: Pulumi is reimagining how teams build cloud software, enabling developers and infrastructure experts to work better...Local areaRemote workFlexible hours$180k - $210k
...the power already available to them. We are seeking a DevOps Engineer to help design, build, and operate Utilidata’s off‑device platform... ..., SRE, or distributed systems, with clear senior or principal-level impact Experience designing and operating infrastructure...Local areaRemote workFlexible hours$185k - $215k
...team supports NBC News' mobile and OTT engineering organization by building shared libraries... ..., and at scale. We are seeking a Principal Engineer to play a critical role in the... ...~8+ years of professional software development experience or equivalent industry...Work at officeLocal areaWorldwide$184.5k - $246k
...technical direction for Medidata's Platform engineering organization - the systems,... ...organization - not just tool adoption, but how software is designed, reviewed, tested, and... ...multiple teams and systems 3+ years in a Principal Engineer, Distinguished Engineer, or...Hourly payOngoing contractWork at officeLocal areaRemote workFlexible hoursShift work$204.25k - $285k
...changing career, working for one of the world's leading financial institutions, you've come to the right place. As a Principal Software Engineer at JPMorganChase within the Consumer & Community Banking Card Technology, you provide expertise and engineering...- ...life here and beyond. Mission: Why this role exists The Engineering Team enables Shiftsmart to anticipate and creatively solve... ...participate in scaling our team Competencies: Who you are A software expert: You have 7+ years of software engineering experience....Hourly payWork experience placementWork at officeFlexible hoursShift workNight shiftWeekend work3 days per week
$209k - $300k
...in the enterprise and to advance our platform technology. ABOUT THE ROLE We are seeking a highly skilled and driven Principal Software Engineer with a strong background in full-stack development, particularly in backend technologies and Agentic AI, to join our AI...Work at officeLocal areaRemote work3 days per week
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Principal Software Engineer, ePrescribing. Be the first to apply!
- principal software engineer New York, NY
- senior principal software engineer New York, NY
- principal applied scientist New York, NY
- senior principal cloud computing engineer New York, NY
- principal software architect New York, NY
- associate principal New York, NY
- senior principal scientist New York, NY
- principal consultant New York, NY
- epic principal trainer New York, NY
- principal data scientist New York, NY


