Biologist

Job Family:
Research Scientists (SCI)

Travel Required:
None

Clearance Required:
Ability to Obtain Public Trust

What You Will Do:

We are looking for a Biologist to support drug repurposing screening projects, disease model development, assay development, and scientific research activities for the National Center for Advancing Translational Sciences (NCATS). This is a full-time position located in Rockville, MD.

• Work with assay providers for assay development and assay transfer to the TDB program.
  
• Perform assay development, optimization, and miniaturization activities.
  
• Conduct high throughput screening using known drugs and bioactive compounds to identify active compounds.
  
• Confirm primary hits and perform secondary and tertiary assays to narrow candidates to top lead compounds.
  
• Perform mechanistic studies to characterize lead compounds when necessary.
  
• Evaluate and apply new technologies and instruments to establish physiologically relevant disease models.
  
• Characterize human induced pluripotent stem cells (iPSCs) and iPSC-derived cells, including developmental marker analysis and disease phenotype studies.
  
• Establish human iPSC-derived cell-based assays for disease modeling.
  
• Lead assay development and compound screening using high-content imaging and flow cytometry assays.
  
• Operate and maintain high throughput flow cytometry instrumentation, including the iQue flow cytometer.
  
• Maintain accurate scientific records and communicate effectively with collaborators and project teams.
  
• Present research findings at internal and external scientific meetings.
  
• Write, submit, and support the publication of scientific manuscripts.
  
• Assist team members with manuscript preparation and revisions.
  
• Collaborate with staff scientists, postdoctoral fellows, IRTA fellows, and external collaborators.
  
• Mentor and train postbaccalaureate IRTA fellows and summer students.
  
• Support the overall operational and scientific objectives of NCATS research programs.
  
• Incumbent capture, no other candidates were considered due to incumbent candidate identified. They meet the labor category requirements provided by the customer
  

What You Will Need:

• Ph.D. in Molecular, Cell Biology, or Biological Sciences.
  
• Minimum of EIGHT (8) years of experience in flow cytometry assays.
  
• Experience in assay development, high-content imaging assay analysis, compound screening, and lead identification.
  
• Experience with in vitro and in vivo disease model systems.
  
• Proficiency with FlowJo, GraphPad Prism, and Microsoft Office.
  
• Strong oral and written communication skills.
  
• Demonstrated ability to write scientific manuscripts and present scientific data and research findings.
  
• Ability to maintain accurate laboratory documentation and records.
  
• Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.
  

What Would Be Nice To Have:

• Background supporting drug repurposing programs.
  
• Ability to work independently and collaboratively in a multidisciplinary research environment.
  
• Hands-on use of high throughput screening platforms and technologies.
  
• Ability to establish disease models using human primary cells or iPSC-derived cells.
  
• Skilled in mentoring junior researchers, fellows, and students.
  
• Collaborative approach with external scientific partners and multidisciplinary project teams.
  
• Scientific publication record in peer-reviewed journals.
  
• Track record presenting research at national or international scientific conferences.
  

The annual salary range for this position is $115,200.00-$172,800.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical, Rx, Dental & Vision Insurance
  
• Personal and Family Sick Time & Company Paid Holidays
  
• Parental Leave
  
• 401(k) Retirement Plan
  
• Group Term Life and Travel Assistance
  
• Voluntary Life and AD&D Insurance
  
• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
  
• Transit and Parking Commuter Benefits
  
• Short-Term & Long-Term Disability
  
• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
  
• Employee Referral Program
  
• Corporate Sponsored Events & Community Outreach
  
• Care.com annual membership
  
• Employee Assistance Program
  
• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
  
• Position may be eligible for a discretionary variable incentive bonus
  

About Guidehouse

Guidehouse is an Equal Opportunity Employer-Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

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