Staff Business Analyst

Staff Business Analyst

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer.

We are seeking a highly motivated Staff Business Analyst with a strong background in genomics and oncology to join our team. You will be embedded at the front of product development for Guardant Health's clinical and genomic data applications. You bring years of direct experience in molecular diagnostics or clinical oncology, and you use that depth daily to shape what gets built, how clinical data is modeled, and what it means for every downstream consumer.

Responsibilities

• Stakeholder Engagement: Collaborate with domain owners and business leaders in Real-World Evidence, Medical Affairs, Biopharma, Product management, and Data Engineering to gather and document business requirements. Ensure clarity of needs and objectives specific to genomic data analytics and real-world clinical outcomes.
• Product Partnership: Operate as part of the product and engineering team, owning the problem space from early discovery through production release. Shape what gets built by driving clarity on requirements, domain and business context.
• Requirements Ownership: Own requirements end-to-end for clinical and genomic data products. Drive conversations with domain authority, challenge assumptions, identify gaps, and resolve ambiguity independently.
• Impact Analysis: Assess the full downstream impact when a new assay, product, biomarker, or data source is introduced including changes to how clinical concepts are represented across the platform, data model and business logic updates, and implications for downstream consumers.
• Data Stewardship: Maintain authoritative documentation of clinical data models, business rules, data mappings, and lineage. Serve as the source of truth for how clinical and genomic concepts are represented and consumed across the platform.
• User Democratization: Serve as a subject matter expert in oncology and genomic data workflows, providing guidance to users and stakeholders. Facilitate user training and support the adoption of new product features.

Qualifications

• 7+ years as a Business Analyst or equivalent, with the majority spent in genomics, molecular diagnostics, oncology, clinical data systems, or precision medicine.
• Deep domain experience is required
• Bachelor's or advanced degree in Life Sciences, Bioinformatics, Genomics, Health Informatics, or a related scientific discipline.
• Expert-level written and verbal communication, documenting data specifications, and stakeholder communications that are clear, precise, and actionable without further interpretation.
• Hands-on experience building or supporting clinical or genomic data applications. Querying data, running data analysis on analytics databases.
• Deep working knowledge of genomic data: variants, biomarkers, assay panels, clinical annotations, and how these translate into structured data within production systems.
• Experience in HIPAA-compliant healthcare environments.
• Familiarity with clinical data governance and data quality standards.
• AI & Digital Fluency: Demonstrate curiosity, sound judgment, and the ability to critically evaluate and responsibly leverage AI-enabled tools in accordance with company policies, ethical standards, and regulatory requirements to improve the efficiency, effectiveness, and quality of work.

Hybrid Work Model: This section is applicable to onsite employees who are eligible for hybrid work location as specified by management and related policies. Guardant has defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.

The annualized base salary ranges for the primary location and any additional locations are listed below. This range does not include benefits or, if applicable, bonus, commission, or equity. Each candidate's compensation offer will be based on multiple factors including, but not limited to, geography, experience, education, job-related skills, job duties, and business need.

• Primary Location: Palo Alto, CA Primary Location Base Pay Range: $142,300 - $195,700
• Other US Location(s) Base Pay Range: $120,955 - $166,345
• If the role is performed in Colorado, the pay range for this job is: $128,070 - $176,130

Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to View email address on click.appcast.io A background screening including criminal history is required for this role. GH will consider qualified applicants with criminal arrest or conviction histories in a manner consistent with applicable law including but not limited to the LA County Fair Chance Policies and the Fair Chance Act (Gov. Code Section 12952). Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. All your information will be kept confidential according to EEO guidelines. To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants.