Manager, Information Security & Technology

A-Alpha Bio is an early-stage and rapidly growing drug discovery company headquartered in Seattle, WA. We are enabling the next generation of high-impact therapeutics by combining high-throughput synthetic biology to measure protein-protein interactions at scale with state-of-the-art machine learning to predict how proteins bind. We partner with leading pharmaceutical and biotechnology companies to enable the discovery of antibodies, molecular glues, and other protein interaction-related drugs. In parallel, we use our wet-lab and computational platforms to discover and develop an internal pipeline of biologics and molecular glues to improve human health. This role is not open to remote applicants and would require relocation to Seattle, WA. Starting Salary Range: $135,000 - $169,000 annually Exemption Status: Exempt Location Expectations : Hybrid Reporting To : VP, Finance & Operations Role Description A-Alpha Bio is seeking a Manager, Information Security & Technology to own and lead our information security and technology program – encompassing information security, cloud infrastructure, laboratory technology, and technology governance. Success in this role depends on a combination of strategic planning and technical implementation, the ability to build strong internal and external partnerships, and a sense of ownership and accountability for technology outcomes. This position will require direct ownership, execution, and vendor management, rather than delegation through a dedicated internal team. Key Responsibilities Cybersecurity Program Own the company’s cybersecurity program and NIST-aligned roadmap. Maintain security policies and procedures, control reviews, and corrective actions. Manage risk assessments, penetration testing, and vulnerability remediation. Develop security metrics, risk reporting, and executive dashboards. Coordinate awareness and phishing training; support customer security reviews and questionnaires. Cloud & Infrastructure Lead AWS infrastructure and security improvements from risk assessments and operational reviews. Manage cloud identity, access, encryption, logging, and monitoring. Support disaster recovery and business continuity, partnering with Data Science on secure, maintainable cloud environments. Network & Systems Own office and laboratory network security and architecture. Assess, design, and implement network segmentation between corporate and laboratory environments, including compensating controls for legacy laboratory systems. Manage firewalls, DNS, secure connectivity, and network access controls. Support lab device and instrument integration, partnering with the MSP on reliable infrastructure. Microsoft 365 & Identity Administer Microsoft 365 and Entra ID, including Conditional Access, Intune, identity governance, and endpoint security. Manage application registrations, enterprise applications, user provisioning, and privileged access reviews. Enterprise Applications Own administration and governance of key SaaS and enterprise applications with business owners, including access, licensing, integrations, and vendor escalations. Coordinate response to application outages and service issues. AI & Technology Governance Establish AI governance and secure-use standards, including an inventory of approved AI tools and platforms. Review technology vendors and SaaS applications for security risks. Technology Program & Vendor Management Own MSP and security vendor relationships, performance, and accountability. Lead technology, infrastructure, and security projects end-to-end, coordinating changes organization-wide. Develop a multi-year technology roadmap and recommend appropriate investments in security, efficiency, and scalability. Qualifications & Experience Required Bachelor’s degree in a related field with 7+ years of experience in IT, cybersecurity, cloud administration, or technology operations; or an equivalent combination of education and experience. Hands‑on experience administering and securing AWS cloud environments, Microsoft 365, and Entra ID. Experience implementing and operating a cybersecurity program aligned with the NIST Cybersecurity Framework (or comparable), including risk management, vulnerability remediation, governance, and vendor and MSP oversight. Experience leading cross‑functional cybersecurity, cloud, and infrastructure initiatives end‑to‑end through influence and technical expertise. Ability to communicate technical concepts and risks to technical and non‑technical audiences. Strong writing skills in regards to policies, executive summaries, and customer‑facing security responses. Ability to develop pragmatic, fit‑for‑purpose solutions that balance security, laboratory, scientific, and business needs. Preferred Professional certifications (CISSP, CISM, Security+, AWS, Microsoft, etc.). Experience supporting regulated environments (life sciences, biotech, healthcare, SaaS). Experience with Microsoft 365 security controls and AWS networking and security. Experience with AI governance or emerging technologies. Experience supporting laboratory or scientific computing environments. We offer competitive compensation, including benefits, flexible time off, and equity in a fast-growing start-up. Applicants must have legal authorization to work in the United States. At this time, A-Alpha Bio is unable to offer visa sponsorship in any form. About A-Alpha Bio A-Alpha Bio is a biotechnology company that leverages synthetic biology and machine learning to measure, predict, and engineer protein-protein interactions. Our AlphaSeq platform applies synthetic biology to experimentally measure millions of protein interaction affinities simultaneously. Protein binding data is incorporated into our AlphaBind platform to train machine learning models that predict binding from sequence. We use both platforms to discover and optimize high-impact therapeutics for our pipeline and in partnership with leading pharmaceutical and biotechnology companies. In 2018, A-Alpha Bio spun out of the University of Washington’s Institute for Protein Design and Center for Synthetic Biology – both communities filled with brilliant and highly entrepreneurial scientists. Since the company’s inception, we have focused on an oncology-centered internal pipeline along with pharma and biotech partnerships to collaboratively train predictive machine learning models and discover and optimize drugs for therapeutic areas ranging from infectious disease to neurodegeneration. New members of the team should expect a fast-paced, highly dynamic, and interdisciplinary work environment. We are building a diverse, meritocratic, and supportive team that shares our values of speaking the truth, shooting for the moon, taking the reins, playing for the team, and improving the world. A-Alpha Bio is headquartered in a custom designed lab and office space in downtown Seattle’s Belltown neighborhood. While the startup lifestyle occasionally requires grueling hours, we strongly value the need for a work-life balance. We are fortunate to be situated in a region that is renowned for its premier outdoor activities, including hiking, biking, climbing, skiing, kayaking, sailing, and more. At A-Alpha, you’ll find many who love the outdoors, but also gamers, amateur chefs, explorers, sports fans, bakers, crafters, photographers, brewers, jetsetters, animal lovers, and artists. Whatever your passions, you belong at A-Alpha Bio! #J-18808-Ljbffr Madrona Venture Labs