Scientist / Senior Scientist, Immunology

Typewriter Therapeutics is a genome engineering and next-generation gene therapy company. Through repurposing a class of genetic elements from various natural genomes, Typewriter Therapeutics aims to develop an all-RNA-mediated gene writing platform via nonviral delivery to address unmet therapeutic needs. Role Description We are seeking a highly motivated, collaborative and resourceful scientist/senior scientist with extensive experience in CAR-T and T cell biology. The successful candidate will be a key member of the immunology team, to enable both early-stage discovery research efforts as well as the development of drug product formulations for our preclinical animal study candidates. This is a hands-on, on-site laboratory role. This individual will be responsible for the design and optimization of our CAR-T in vitro assays and will interface with cross-functional teams including delivery, analytical, pharmacology, and manufacturing to advance platform initiatives and pipeline programs. The ideal candidate will have a proven track record of developing CAR-T in vitro assays (including co-cultures, cytokine release assays, immunophenotyping, CAR-T cell expansion, flow cytometry, ex-vivo processing, etc). Previous experience with LNPs, pharmacology, CAR-T design, and gene editing is a plus. The candidate is expected to be a strong collaborator who enjoys scientific discovery, has a passion for working on cutting-edge technology, and can communicate effectively in a fast-paced, dynamic, and interdisciplinary environment. Responsibilities Design, implement, and execute T cell in vitro assays including (but not limited to) CAR-T co-cultures, cytokine release assays, immunophenotyping, CAR-T cell expansion, flow cytometry, and ex-vivo processing Collaborate with external CROs Maintain meticulous documentation of all experimental data, procedures, and protocols Review and analyze data and be able to present and explain across the functional teams Collaborate with a team of scientists to creatively solve problems and drive innovation Maintain high standards for scientific integrity and accountability Requirements PhD in immunology, cell biology, pharmacology, or related discipline, MS with at least 4 years of relevant industry experience, BS with at least 7 years of relevant industry experience Hands on experience with the following: CAR-T, flow cytometry, primary cell (immune cells) and cell line culturing, co-cultures, ex-vivo processing, T cell immunophenotyping, cytokine release assays, qPCR, electroporation Able to conduct self-directed research and thrive in a dynamic and fast-paced entrepreneurial setting with a diverse team of coworkers Exceptional problem-solving skills, outstanding interpersonal skills, creativity, enthusiasm, and reliability Strong organizational skills, attention to detail, and meticulous data documentation Ability to prioritize multiple tasks while maintaining accuracy Effective verbal and written communication skills for cross-functional collaboration Flexibility to adapt to evolving project priorities in a dynamic environment Scientifically curious, paired with a strong work ethic and grit Open-minded, respectful of others, and a strong proponent of an inclusive culture Embraces the lean start-up mentality and is willing to wear multiple hats Seniority level Mid-Senior level Employment type Full-time Job function Research, Analyst, and Information Technology #J-18808-Ljbffr Typewriter Therapeutics, Inc.