Senior Scientist/Principal Scientist, In Vivo Pharmacology

Scribe Therapeutics is a clinical-stage biotechnology company engineering CRISPR-based technologies into purpose-built in vivo genetic medicines designed to become standard of care treatments for patients suffering from highly prevalent diseases, starting with cardiometabolic disease. Leveraging its CRISPR by Design™ approach and nature’s blueprint for improved cardiovascular health, Scribe’s initial programs focus on addressing the key drivers of ASCVD such as elevated LDL-C, lipoprotein(a), and triglycerides. The company’s lead candidate, STX-1150, is a novel liver-targeted therapy designed to epigenetically silence the PCSK9 gene and reduce LDL-C levels without inducing permanent DNA changes. To broaden and accelerate the impact of its engineered CRISPR technologies for patients, Scribe has formed strategic collaborations with world-leading pharmaceutical companies including Sanofi and Eli Lilly. Co-founded by Nobel Prize winner Jennifer Doudna and backed by leading life sciences investors, Scribe is advancing scalable, transformative, and preventative genetic medicines with the goal of improving outcomes and democratizing access to the protective effects of beneficial human genetics.

• __________________________________________________________________________________ Position Summary: We are seeking a highly creative, passionate, and motivated individual to join us in our quest to bring the next generation of CRISPR-based therapeutics into the regulatory submission framework. The current role is for an Senior Scientist/Principal Scientist, In Vivo Pharmacology. The candidate will be responsible for providing in vivo pharmacology support for the Company’s product portfolio and pipeline from early-stage development through regulatory submission and clinical trial development. This role will require hands on in-vivo work as well as interaction with CROs for outsourcing research and potentially IND enabling in-vivo studies.
• __________________________________________________________________________________ NHP Pharmacology and Toxicology Study design and management at CROs

Bioanalytical assay development Protocol development and report writing Teamwork ___________________________________________________________________________________ Key Duties / Responsibilities / “What you’ll do”: Lead the in vivo pharmacology aspect of multiple projects within discovery and development, provide in vivo physiology and pharmacology expertise. Propose, plan, coordinate, and supervise study execution at external CROs. Develop and implement new animal models to support multiple gene editing targets. Plan and conduct in vivo pharmacology studies: formulation and administration of gene editing therapeutics. Analyze data from in vivo pharmacology and efficacy studies and perform statistical analysis. Communication of experimental plans and data to multiple cross-functional scientific teams. Contribute to preparation of study reports, regulatory filings, and project presentations. Maintain excellent written documentation of completed experiments (e.g. electronic lab notebook and study reports). Mentor early-career scientists on the team. Requirements Knowledge Requirements (Background/Skills/Experience): PhD degree in biology, biomedical engineering, pharmacology/toxicology, or related field with 2-4 years of post-graduation experience in industry (preferred) or academia performing in‑vivo experiments. Experience planning and executing in‑vivo studies, data analysis, and interpretation. Previous experience with CRISPR based gene editing is a plus. Extensive experience working with small laboratory animals and well‑established hands‑on experience with in vivo dosing, bleeding, necropsy and tissue collection. Experience planning and executing bioanalytical experiments including but not limited to ELISA, Western blots, and RT-qPCR. Attention to detail, critical analysis of data and troubleshooting abilities. Good writing and communication skills; ability to understand and communicate scientific information. Highly collaborative working style, and ability to adapt in a fast‑paced environment. Ability to work with minimal direction to meet objectives and timelines, adapting to changes and priorities to fulfill our mission ___________________________________________________________________________________ Physical Requirements: Prolonged periods of sitting at a desk and working on a computer. Must be able to lift up to 15 pounds at times. Summary Benefits & Compensation: Salary and total compensation will be commensurate with experience and will include a competitive benefits package. Scribe provides an intellectually stimulating, collegial, and fast‑paced environment. Health: Medical (HMO, PPO, EPO, HDHP), Dental, Vision, Life, Transit, FSA, HSA Equity: Meaningful equity that allows you to share in the long‑term success of the platform. Perks: Wellness stipend, Learning and development opportunities, Cell stipend, home office set up stipend. Equal Opportunity Employer We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status, or any other characteristic protected by applicable law. #J-18808-Ljbffr Scribe Therapeutics