Director Clinical Pharmacology & DMPK
$200k - $240kAlumis
Job Description
Job Description
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.
Alumis is seeking a Director of Clinical Pharmacology & DMPK to drive clinical pharmacology strategy and PK/PD modeling for our small-molecule programs in immune-mediated diseases. This role partners closely with cross-functional teams and reports to the Head of Clinical Pharmacology & DMPK.
Specific responsibilities include but are not limited to:- Lead clinical pharmacology strategy, dose selection, and PK/PD and biomarker planning across early and late-stage programs.
- Conduct and interpret PK, PK/PD, exposure–response, and simulation analyses using tools such as NONMEM, WinNonlin, R, Python, and Simcyp.
- Integrate translational and nonclinical PK/PD data to support FIH dose projections and DDI assessments.
- Oversee bioanalytical CROs, ensuring high-quality PK/PD/biomarker data and GLP/GCP compliance.
- Partner with Clinical Operations on sample management and protocol design.
- Communicate quantitative findings clearly and contribute to regulatory documents (protocols, IBs, INDs, NDAs, IMPDs).
- Collaborate across Clinical Development, Biostats/Data Science, Nonclinical, and Program Management.
- PhD, PharmD, or equivalent in Pharmacokinetics, Pharmacology, or related field.
- 6 to 8+ years of industry experience in Clinical Pharmacology, DMPK, or Quantitative Pharmacology.
- Strong expertise in PK, PK/PD, DMPK, and translational sciences.
- Proficiency with modeling/simulation platforms (NONMEM, WinNonlin, Simcyp, R, Python).
- Excellent communication, organization, and ability to work independently in a fast-paced environment.
The salary range for this position is $200,000 USD to $240,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company's compensation practices.
This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday.
Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program.
Other benefits include:
- Health insurance premiums paid at 90% for employee, 80% for dependents
- Free access to Genentech Bus & Ferry Share program
- $100 monthly cell phone stipend
- Unlimited PTO for Exempt employees
- Free onsite gym and a kitchen stocked with yummy snacks and drinks!
We are a hard-working, collaborative team on a mission to transform patient's lives-- and we aspire to elevate , challenge and nurture one another along the way.
Alumis Inc. is an equal opportunity employer.
Vacancy posted a month ago
Similar jobs that could be interesting for youBased on the Director Clinical Pharmacology & DMPK in South San Francisco, CA vacancy
$235.5k - $329.5k
Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering... ...is looking for an experienced Sr. Director of Clinical Pharmacology and Translational PK/PD to lead the... ...experience in Clinical Pharmacology, DMPK and/or related fieldsMastery of...SuggestedFull timeWork at officeWork visa3 days per week$275k - $360k
...peptide drugs. We are advancing a clinical‐stage pipeline of... ...Summary: The Head of Clinical Pharmacology will work with cross functional... ...as a subject matter expert in DMPK, classical and quantitative clinical... ...collaborators, board of directors, investors, key opinion leaders...SuggestedContract work- ...visit us at Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube. Job Description Communicates/presents key Clinical Pharmacology information/strategy to senior and executive management, regulatory agencies, and external peers. Supports strategic...SuggestedLocal area
AbbVie
South San Francisco, CA20 days ago $270k - $360k
...Medical Director/Senior Medical Director, Clinical Development Tenvie Therapeutics is developing precision‑engineered small molecule therapies... ...interactions Partner with Biostatistics, Clinical Pharmacology, and Translational Science on endpoint hierarchy, statistical...SuggestedFull timeLocal areaRemote workTenvie Therapeutics
Brisbane, CAmore than 2 months ago$220k - $250k
Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming... ...and for what’s beyond.About the Role >>> Director, Clinical ScienceAs the Director,... ...Data Management, Biostatistics, Clinical Pharmacology, Regulatory and Program Management, in...SuggestedWork at officeFlexible hours$230k - $300k
...engager programs, led by a potential first‑in‑class clinical asset and complemented by an exciting preclinical portfolio... ...forward to meeting you.The RoleWe are seeking a Director or Senior Director of Clinical Pharmacology to lead clinical pharmacology strategy and execution...Contract work$226.19k - $292.71k
...developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.Job DescriptionAs a Director within the Clinical Pharmacology Group at Gilead, you will have significant responsibility and accountability for clinical pharmacology programs in...Full timeFor contractorsLocal area- ...knowledge to ensure excellence in development and translation of clinical research plans into efficiently delivered studies.• The Non-MD... ...responsible for developing methodologies to support proof of pharmacology, proof of mechanism, proof of concept.• The Non-MD/Study...Immediate start
- Structure Therapeutics is seeking the Head of Clinical Pharmacology to lead the DMPK and clinical pharmacology efforts across discovery through regulatory filings. You will mentor scientists, manage vendors, and build capabilities in the US and China, partnering with cross...
$144k - $240k
...mediated diseases by developing novel targeted therapies with outsized clinical impact, faster. To accomplish this, we are seeking top talent to join us on our journey.As the Lead, Clinical Pharmacology, Immunology, you will serve on program and study teams, providing...Temporary workLocal area$300k - $400k
...Alumis is seeking an experienced Executive Medical Director or Senior Medical Director to lead clinical development strategy and execution for Phase 1 and... ...closely with Translational Sciences, Biomarker, and Pharmacology teams to integrate biomarker strategies into clinical...Remote workAlumis
South San Francisco, CAa month ago$275.63k - $334k
...Director, Global Clinical Physician - Early Clinical Development Oncology Working with Us Challenging. Meaningful. Life-changing. Those... ...studies, biomarker qualification studies, and/or clinical pharmacology studies Liaises with Clinical Scientists, Translational...Hourly payFull timeTemporary workPart timeSummer workWork at officeRemote workWorldwideFlexible hours$235.5k - $329.5k
Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering... ...their best.THE OPPORTUNITYThe Senior Director, Clinical Research Oncology will provide... ...of clinical, translational, pharmacology, biometrics, and regulatory perspectives...Full timeWork at officeWork visa$176.6k - $236.6k
...Medicines is seeking an accomplished scientific leader to serve as Director, Clinical Biomarkers & Translational Medicine within the Oncology... ...with Discovery Research, Clinical Development, Clinical Pharmacology, Precision Medicine, Bioinformatics, Biostatistics,...Hourly payFull timeContract workLocal areaBeiGene
San Carlos, CA6 days ago- ...Job Description Job Description Title: Associate Director, Clinical Pharmacology Location: Thousand Oaks, CA or San Francisco, CA Company Description: Latigo Biotherapeutics, Inc. is a private, early-stage biotechnology company focused on discovering and...Work at office
Latigo Bio
San Francisco, CAa month ago - Medical directors of Oncology Clinical Research - San Francisco Tanner and Associates is recruiting several Medical directors of Oncology Clinical... ..., biostatistics, clinical operations, regulatory and pharmacology for input/alignment and presentation at the Therapeutic...Interim role
$205k - $250k
...limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic... ...impactful contributions to AI integration Position Summary:The Director, Clinical Trial Finance will lead financial planning and oversight...Contract workWork at office$237k - $285k
...limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic... ...impactful contributions to AI integration Position Summary: The Director of Clinical AI Technologies is responsible for translating clinical...Contract workRemote work$181k - $221k
...rare diseases. As Sr. Project Manager, Clinical Operations, you will play a critical role... ...Operations Study Leads, Oversight Directors, and cross-functional teams to support... ...successful execution of multiple clinical pharmacology studies, early-phase studies, Phase 2 studies...Full timeWork at officeMaze Therapeutics
South San Francisco, CA7 days ago- ...Instagram , X and YouTube. Job Description Conceives, executes and effectively manages and communicates multi-disciplinary Clinical Pharmacology development plans and strategies that achieve commercial goals and regulatory requirements for multiple functions. Generates...Full timeLocal area
- ...health challenges of our day and improving the lives of patients for generations to come.We are looking for an Associate Director, Clinical Pharmacology based in our Foster City, CA office or Parsippany, NJ office, supporting drug development in Virology, Pediatrics...Full timeFor contractorsWork at officeLocal areaFlexible hours
- ...Description Job Description The position of Medical Director will be an essential part of the clinical development team and will report to the Chief... ...decisions. Familiarity with the general principles of pharmacology/toxicology as it relates to first-in-human studies...Work at officeRelocation
Attovia Therapeutics
San Carlos, CAmore than 2 months ago - ...San Francisco, CaliforniaCompany: Planet Pharma GroupContact: ApplicationsEmail: ****@*****.*** Summary: Clinical Contracts consultant Seeking an Corporate and Clinical Contracts consultant, who will be an integral member of the Legal Department...Contract work
- Director, Clinical Trial Finance Our client, a publicly traded life sciences company, is seeking a Director of Clinical Trial Finance to lead financial planning, forecasting, and oversight activities across a portfolio of clinical development programs. Location: San Francisco...Work at officeLocal area3 days per weekSouth San Francisco, CA3 days ago
$230k - $270k
...Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of... ...the role: We are looking for a talented, motivated Senior Director to join our Portfolio & Program Management Team as a key leader...Full timeLocal areaRemote workAllogene Therapeutics
South San Francisco, CAmore than 2 months ago$211k - $258.67k
Director, Clinical Regulatory page is loaded## Director, Clinical Regulatorylocations: South San Franciscotime type: Full timeposted on: Posted 2 Days Agojob requisition id: R-1462Neurodegenerative diseases are one of the largest medical challenges of our time. Denali...Temporary workWork experience placementLocal area- Merck & Co. is seeking an Executive Director, Clinical Science to lead a large team responsible for infectious diseases and vaccines across multiple development stages. The role partners with Clinical Operations, Regulatory Affairs, Biostatistics, Pharmacovigilance, Translational...
$255.8k - $402.7k
Job Description Brief Description of Position The Executive Director, Clinical Science is a senior leader within Non-Oncology Clinical Development responsible for providing strategic, scientific, operational, and people leadership across a portfolio of cardiometabolic...For contractorsLocal areaImmediate startRelocationVisa sponsorshipFlexible hoursShift work$230k - $270k
Allogene Therapeutics is seeking a Senior Director to lead the Portfolio & Program Management Team in South San Francisco. This role involves managing a cross-functional team to drive execution of key programs in the biotech space. Required qualifications include a Bachelor...- Merck & Co. is seeking an Executive Director, Clinical Science in California to lead oncology drug development across multiple therapy areas. This senior leader will drive strategy, execution, and organizational capability, collaborating with Regulatory, Medical Affairs...
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Director Clinical Pharmacology & DMPK. Be the first to apply!
Related searches
- psychiatry medical director South San Francisco, CA
- remote medical coding supervisor South San Francisco, CA
- clinical data manager remote South San Francisco, CA
- healthcare supervisor South San Francisco, CA
- mental health clinical supervisor South San Francisco, CA
- associate director clinical operations South San Francisco, CA
- medical coding manager South San Francisco, CA
- clinical operations director South San Francisco, CA
- health economics manager South San Francisco, CA
- senior medical director medical affairs South San Francisco, CA