Postdoctoral Scientist, Autonomous NMR Characterization

Organizational Overview We are a global healthcare leader headquartered in Indianapolis, Indiana. Our mission is to discover and deliver life‑changing medicines and to build innovative analytical tools that enable faster, safer discovery science. The Lilly Small Molecule Discovery (LSMD) group focuses on advanced molecular characterization to support medicinal chemistry, process chemistry, and analytical teams. Position Overview Postdoctoral Scientist – Autonomous NMR Characterization (LSMD). The role is to design and build an autonomous, agent‑based NMR platform that selects experiments, optimizes acquisition parameters, and determines when sufficient data has been collected. The platform relies on CRAFT time‑domain processing for data interpretation. Reliant Responsibilities Maintain a strong safety culture in laboratory and computational work. Prepare and characterize pharmaceutical compounds and mixtures, acquiring high‑quality 1D and 2D NMR data on high‑field spectrometers. Develop and validate an autonomous NMR characterization platform that optimizes acquisition parameters, selects experiments, and processes data without operator intervention. Design, set up, and run chemical reactions using modern reaction methodologies and monitor them in situ by NMR to track reactants, intermediates, products, and by‑products. Apply and extend modern analytical and computational methods, including 1D/2D NMR, time‑domain signal processing, Bayesian optimization, machine‑learning property prediction, and multivariate chemometrics. Build reproducible scientific software and closed‑loop instrument automation through the TopSpin Python API and related interfaces, partnering with instrument and software vendors to troubleshoot and extend capabilities. Collaborate across analytical, medicinal, and process chemistry to translate methods into deployed tools and communicate results through publications and presentations. Basic Qualifications PhD in chemistry, analytical chemistry, computational chemistry, cheminformatics, or a related discipline with all requirements completed by October2026. Authorized to work in the United States on a full‑time basis; no work‑authorization sponsorship will be provided. Strong record of scientific contributions, including peer‑reviewed publications, presentations, and/or patents. Demonstrated experience programming scientific data analysis (e.g., Python or R). Preferred Knowledge, Skills, Abilities, and Experience Hands‑on experience acquiring and interpreting 1D and 2D NMR data. Experience with reaction monitoring or in‑situ analytical techniques. Familiarity with additional analytical methods such as LC‑MS, GC‑MS, or IR. Experience with NMR automation or pulse‑sequence‑level work (e.g., TopSpin, IconNMR). Experience with scientific software development and Bayesian optimization, active learning, or autonomous experimentation. Familiarity with multivariate or chemometric analysis (e.g., PCA, PLS, PARAFAC). Expertise in Bruker NMR hardware and TopSpin/IconNMR software; familiarity with data‑processing software such as MestReNova/Mestre or ACD. Proficiency with scientific informatics, data visualization, or data‑management tools that support analytical decision‑making and AI‑enabled workflows. Learning agility and ability to acquire new technical skills rapidly; ability to work productively in interdisciplinary, cross‑functional, and international teams. Excellent English oral and written communication skills for engaging in a multidisciplinary, global team. Additional Information Location: Onsite, laboratories in Louisville, CO. Commitment: Fixed‑term position up to 2 years with a possible 2‑year extension. Physical demands and work environment: Laboratory and office/computational setting with standard chemical‑lab safety equipment required. Compensation and Benefits Anticipated base salary: $58,000 – $123,200, depending on education, experience, skills, and geographic location. Eligibility for company bonus based on individual and company performance. Comprehensive benefit program including 401(k) eligibility, pension, vacation, medical, dental, vision, prescription drug, flexible benefits, life insurance, and well‑being benefits. Equal Opportunity Statement Eli Lilly and Company, Lilly USA, LLC, and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other legally protected status. All employment decisions are based solely on merit and qualifications. Lilly’s employee resource groups provide support for diversity and inclusion across the company. #J-18808-Ljbffr 100 Eli Lilly and Company