Principal Manager, Clinical Operations Lead

Join Immatics and shape the future of cancer immunotherapy; one patient at a time!

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME , a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

Why Join Us?

• Innovative Environment: Help to pioneer advancements in cancer immunotherapy.

• Collaborative Culture: Be part of a diverse team dedicated to your professional growth.

• Global Impact: Contribute to therapies that make a lasting impact on patients globally.

Role Overview

We are seeking a Principal Manager, Clinical Operations Lead to support our Clinical Operations team. The Clinical Operations Lead will be responsible for the oversight, execution, and operational management of US regional clinical trials in support of our clinical development programs.

Reports to : Associate Director, Clinical Asset Management

Location : US, Fully Remote

Salary Range : $165,000 - $180,000

Basic Qualifications:

• Bachelor’s degree in life science, nursing, or similar

• 7+ years of demonstrated leadership of global clinical operations in the pharmaceutical or biotechnology industry including clinical trial oversight, vendor management, and cross-functional study leadership

Preferred Qualifications:

• Master’s Degree, preferably in life science, nursing, or similar

• Noted experience in late phase or launch in oncology.

• Experience cell and/or gene therapy, or other complex biologic clinical development programs

• Demonstrated ability to drive process improvements and operational excellence initiatives

• Ability to understand and navigate complex clinical development processes and cross-functional interdependencies and collaborate with stakeholders outside of Clinical Operations

• Strong analytical and problem-solving skills with the ability to assess operational impact across broader cross-functional environments

• Ability to operate effectively in a fast-paced and evolving clinical research environment

In this role you will:

• Lead clinical trial execution and operational delivery across internal and external stakeholders from study start-up through execution

• Provide oversight of CROs, vendors, and clinical trial partners to ensure quality, compliance, timelines, and budget objectives are achieved

• Serve as the Clinical Operations leader for the team of CTMs, CRAs and CTAs for each assigned project

• Drive risk identification, issue escalation, and mitigation planning across assigned studies

• Support study start up, site feasibility, enrollment, and operational execution activities

• Partner cross-functionally with Clinical Development, Regulatory, Safety, Biometrics, Supply Chain, Program Leadership and external vendors

• Contribute to SOP development, process optimization, inspection readiness, and operational excellence initiatives

• Mentor and coach junior Clinical Operations team members as applicable

What do we offer?

At Immatics, we believe in investing in our team’s health, safety and well-being. Here’s what you can expect if you join Immatics

Comprehensive Benefits :

• Competitive rates for Health, Dental, and Vision Insurance

• 4 weeks of vacation, granted up front each year and prorated for first and last year of employment.

• 12 company paid holidays

• 7 days of sick time

• 100% employer-paid life insurance up to at 1x annual salary, up to one hundred thousand dollars

• 100% employer-paid short- and long-Term disability coverage

• 401(k) with immediate eligibility and company match. The company will match 100% of your contributions up to 3% of your base salary for the first two years of employment, 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment.

• Partially paid parental leave for eligible employees.

• Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance.

Equal Employment Opportunity

We are an equal opportunity employer and are committed to building a diverse and inclusive workplace. We consider all qualified applicants for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, national origin, ancestry, age, marital status, disability, genetic information, veteran status, or any other status protected by applicable law.

Reasonable Accommodations

We are committed to providing reasonable accommodations to individuals with disabilities and to applicants with sincerely held religious beliefs, practices, or observances. If you require assistance or accommodation during the application or interview process, please contact us at View email address on aiapply.co .

Work Authorization

Applicants must be authorized to work in the United States without the need for current or future sponsorship.

Pre-Employment Requirements

Employment is contingent upon successful completion of a background check, reference checks and pre-employment drug screening, where permitted by applicable law. For certain roles, additional screenings such as a credit check or motor vehicle record review may be required, where job-related and consistent with business necessity.