Executive Medical Director - Physician - Early Clinical Development, Aesthetic Medicine

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Position Summary

We are seeking a high-impact physician scientist and emerging industry leader to join our Aesthetic Medicine team as Executive Medical Director, Early Clinical Development. This role is designed for a clinical translational leader ready to step into enterprise influence, bridging the critical gap between discovery science and clinical application, driving the development of transformational medicines for people seeking aesthetic and dermatologic treatments. The successful candidate will serve as a strategic and scientific leader, connecting discovery scientists, translational/biomarker experts, early clinical physicians, clinical pharmacologists, and late-stage clinicians to craft compelling therapeutic hypotheses and efficiently test them in early clinical development with line of sight to full development and approval. This role requires strong matrix leadership, executive presence, and the ability to inspire high-performing teams, influencing cross-functional partners and advancing both internal and external portfolio opportunities to bring transformational treatments to people seeking aesthetic medicine solutions. This position is ideal for a proven industry Director/Sr Director seeking broader leadership scope, enterprise visibility, and the opportunity to help build a dynamic and growing Aesthetic Medicine organization at Lilly.

Primary Responsibilities

Strategic Portfolio Leadership

• Collaborate with discovery, translational medicine, and clinical teams to develop and refine therapeutic hypotheses for aesthetic medicine indications, including skin health and quality, facial aesthetics, and body aesthetics
• Participate in prioritization of target and modality selection, integrating scientific rigor with clinical feasibility, unmet needs, and commercial potential, with particular attention to transformational potential of proposed programs
• Evaluate and diligence external discovery and early clinical opportunities for potential partnerships or acquisitions
• Provide scientific and clinical expertise to portfolio strategy to ensure a robust pipeline of transformational medicines in aesthetic medicine
• Act as a visible strategic leader within the aesthetic medicine portfolio, influencing direction, investment decisions, and development priorities

Clinical Development Excellence

• In collaboration with stakeholders, design early clinical studies that efficiently test therapeutic hypotheses
• Collaborate with clinical pharmacology, biostatistics, regulatory affairs, operations, Health Economics and Outcomes Research (HEOR), and other stakeholders to optimize study design and execution
• Integrate translational endpoints, biomarker strategies, and validated aesthetic scales and patient-reported outcome measures to accelerate and maximize learning from early clinical studies and enable early decision-making
• Contribute to regulatory interactions, including pre-IND, IND submissions, interactions with ex-US health authorities, as well as regulatory strategy development
• Monitor patient safety and ensure compliance with GCP, FDA, ICH guidelines, and company policies
• Drive innovative experimental medicine approaches and accelerate progression from first-in-human through proof-of-concept

Cross-Functional Leadership & Influence

• Serve as scientific and medical expert across multiple therapeutic programs simultaneously
• Lead early clinical strategy in cross-functional teams through matrix influence, aligning diverse stakeholders around common objectives
• Facilitate decision-making processes across discovery, development, and commercial functions
• Mentor and develop junior team members while building scientific capabilities across the organization
• Operate as a culture-shaping leader who elevates performance, accountability, and collaboration across teams

External Partnerships & Scientific Exchange

• Establish and maintain relationships with key opinion leaders and scientific experts in aesthetic medicine, dermatology, and plastic surgery
• Represent Lilly at scientific conferences, advisory boards, and industry forums
• Support business development activities through clinical scientific due diligence
• As appropriate, identify, evaluate, and execute strategic partnerships with CROs, biotech companies, academic institutions, and research organizations to enable the discovery and early development portfolio and strategy
• Enhance Lilly’s external scientific presence as a thought partner and collaborator in aesthetic medicine innovation

Regulatory & Medical Affairs Support

• Partner with regulatory colleagues on IND strategy, FDA interactions, and global development planning
• Contribute medical expertise to regulatory submissions and agency communications
• Support risk management planning and safety signal evaluation
• Participate in data analysis, scientific publications, and medical communications
• Help shape development strategy and regulatory positioning for early-stage aesthetic medicine assets

Minimum Qualifications

• Medical Doctor or Doctor of Osteopathic Medicine. Must be board eligible or certified in Dermatology, Plastic Surgery, or related specialty or have completed the comparable level of post-medical school clinical training relevant to the country of hiring. US trained physicians must have achieved board eligibility or certification. Physicians trained outside the US who are not US board eligible or certified may be hired directly for employment in the US at the discretion of the hiring manager.
• Non-US trained physicians must have completed education and training at a medical school that meets the requirements of the Educational Commission for Foreign Medical Graduates (ECFMG).

Preferred Qualifications

• Minimum 5 years of pharmaceutical/biotechnology industry experience with progression to Director or Sr Director responsibilities in early clinical development
• PhD in Skin Biology, Regenerative Medicine, Pharmacology, or related field strongly preferred
• Demonstrated experience in early-phase clinical trial design and execution in aesthetic indications
• Strong background in translational medicine and biomarker development or application
• Track record of successful cross-functional collaboration and matrix leadership
• Deep understanding of skin biology, the pathophysiology of aging and aesthetic conditions, and the current aesthetic medicine therapeutic landscape
• Experience with novel aesthetic and dermatologic therapeutic approaches (injectables, neuromodulators, biostimulatory agents, biologics, small molecules, regenerative medicines, device-based treatments)
• Knowledge of regulatory requirements for early clinical development (IND/IDE strategy, FDA interactions, global regulatory agencies)
• Familiarity with target identification/prioritization through causal human biology in areas of high unmet need, translational endpoints, biomarker strategies, precision medicine approaches, clinical pharmacology, and pharmacokinetic/pharmacodynamic modeling
• Previous experience in aesthetic medicine, dermatology, or plastic surgery therapeutic areas
• Publication record in peer-reviewed journals demonstrating scientific leadership
• Experience with business development, licensing, or partnership activities
• Previous regulatory interactions and FDA or other health authority meeting experience
• Advanced degree or fellowship training in clinical research or pharmaceutical medicine
• Experience with innovative experimental medicine trial designs and adaptive study approaches
• Demonstrated ability to lead programs, influence strategy, and operate effectively in a fast-moving, high-visibility portfolio environment

Key Competencies

Scientific Leadership:

• Ability to synthesize complex scientific data and translate into actionable clinical strategies
• Strategic thinking and hypothesis generation capabilities
• Critical evaluation of competitive landscape and market opportunities

Matrix Leadership & Influence:

• Exceptional communication and interpersonal skills
• Demonstrated ability to influence without authority and build consensus across diverse teams
• Strong negotiation and conflict resolution capabilities
• Cultural sensitivity and ability to work effectively in a global environment
• Executive presence with the ability to engage senior stakeholders

Execution Excellence:

• Autonomous work style with strong project management capabilities
• Results-oriented mindset with focus on patient impact and business objectives
• Adaptability and resilience in a fast-paced, evolving environment
• Strong analytical and problem-solving skills

External Engagement:

• Ability to build and maintain relationships with external scientific and clinical community
• Strong presentation and public speaking capabilities
• Professional network within the aesthetic medicine, dermatology, and plastic surgery research community
• Credibility as an emerging external scientific leader in aesthetic medicine

Additional information and expectations

• Travel: 10-15% domestic and international travel required
• Location: Boston, San Diego, San Francisco, Indianapolis
• Reports to: Head of Early Clinical Development, Immunology&Aesthetic Medicine
• Matrix relationships: Extensive collaboration across Discovery, Translational Medicine, Clinical Pharmacology, Quantitative Systems Pharmacology, Clinical Operations, Regulatory Affairs, and Search and Evaluation/Business Development
• Opportunity to play a foundational leadership role in a rapidly expanding Lilly Aesthetic Medicine organization with strong executive sponsorship and pipeline momentum

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (View email address on joinrs.com), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL). Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $217,500 - $389,400 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. #WeAreLilly