Goodarzi Lab - Junior Specialist

Position Description Goodarzi Lab – Junior Specialist Department of Biochemistry and Biophysics, UC San Francisco We are seeking a highly motivated and detail‑oriented Junior Specialist to support research in RNA‑based therapeutics and cancer biology. The candidate will work closely with postdoctoral fellows and other lab members to investigate novel approaches in RNA delivery, stability, and expression in the context of cancer models. Key Responsibilities Conduct molecular biology experiments such as PCR, in vitro transcription (IVT), cloning, and Western blotting. Perform luciferase‑based reporter assays and qPCR to assess RNA activity. Maintain mammalian cell cultures and execute in vitro RNA transfection experiments using lipid nanoparticles (LNPs). Prepare DNA libraries for next‑generation sequencing. Perform flow cytometry and immunostaining‑based assays. Assist in animal studies, including tumor cell injections (subcutaneous, intravenous), in vivo RNA delivery, and tissue harvesting. Collect, analyze, and present experimental data. Contribute to routine lab maintenance and reagent preparation. This position offers opportunities for scientific growth, including participation in collaborative research, lab meetings, and publications. Required Qualifications Must have (or be in the process of obtaining) a baccalaureate degree (or equivalent) in molecular biology, biochemistry, cell biology, cancer biology, bioengineering, or a related field; or at least four years of relevant research experience to be appointed at the Junior rank. Willingness to work with mice. Strong organizational skills and the ability to work independently and as part of a team. Excellent written and oral communication skills. Preferred Qualifications Hands‑on experience with in vivo tumor models, including tumor cell injections, tissue harvesting, and LNP/RNA delivery in mice. Experience with PCR, cell culture, qPCR, in vitro transcription (IVT), luciferase assays, and flow cytometry. Familiarity with RNA biology, gene expression assays, and Western blotting. Proficiency in data analysis and visualization using tools such as GraphPad Prism, FlowJo, ImageJ, or similar software. Prior experience working in an academic or biotech research lab. Salary: $55,000–$58,600. Equal Opportunity Employer The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or any other protected status under state or federal law. Condition of Employment The finalist will be required to disclose any final administrative or judicial decisions within the last seven years that determined they committed misconduct. San Francisco, CA #J-18808-Ljbffr University of California, San Francisco