Lead Researcher In Vivo & In Vitro Screening

We are seeking a motivated and detail-oriented Lead Researcher to investigate therapeutic approaches for pediatric cancers with a focus on leukemia and medulloblastoma. Our research integrates cancer biology molecular biology functional genomics and translational science.

The successful candidate will lead and support in vitro and in vivo drug screening including dose-response combination therapy and synergism studies and use molecular and cellular approaches to define mechanisms of drug response. Projects will incorporate short and long-read RNA sequencing and other genomic approaches to generate mechanistic insights with validation using molecular biology and cell-based assays. The ideal candidate will have hands-on experience in molecular and cell biology including cell culture flow cytometry DNA/RNA isolation western blotting and functional assays. Experience with drug screening genomics cancer models or in vivo studies is highly desirable. This position offers an exciting opportunity to contribute to translational research aimed at developing improved therapies for children with cancer.

This Position May be Ideal For:

• Masters level graduates with extensive laboratory experience looking to establish a track record of research productivity including gaining high-position authorships on publications.
• Recent PhDs or research staff looking for an enriching collaborative and interdisciplinary lab environment committed to discovering new biology in the field of high-risk leukemia research.

Job Responsibilities:

• Lead and performin vitro and in vivo drug screeningstudies using established primary and patient-derived leukemia and medulloblastoma models

• Design and executedose-response viability combination and drug-synergy studies

• Develop optimize and troubleshootcell-based and molecular assays

• Utilizeshort- and long-read RNA-seqand other genomics approaches to investigate mechanisms of therapeutic response

• Analyze and interpret experimental data prioritize candidates to advance studies towardin vivo validation

• Design and/or coordinatein vivo efficacy studies

• Maintaincomprehensive and well-organized experimental records

Minimum Education and/or Training:

• Bachelors degree in a relevant scientific area is required

Minimum Experience:

• 5 years of research experience is required
• 3 years of experience is required with a Masters degree
• No prior experience required with a PHD
• Strong knowledge and experience in understanding and application of underlying principles related to techniques being performed
• Experience in R&D methods and processes in lab setting and execution of research projects for the laboratory preferred
• Proven performance in earlier role/comparable role

Compensation

In recognition of certain U.S. state and municipal pay transparency laws St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets experience and training licensure and certifications and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $60320 - $105040 per year for the role of Lead Researcher - In Vivo & In Vitro Screening.

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Required Experience:

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