Senior Director, Portfolio Integration Lead

DescriptionFor candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Cambridge. The location of this role will therefore subsequently change to Cambridge in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.Business IntroductionAt GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together.Find out more:Our approach to R&DJob Title: Senior Director, Portfolio Integration LeadOverview Cancer is unrelenting, but so are we. At GSK, we are committed to transforming outcomes for people with cancer through innovative science, bold ambition, and strong partnerships across the healthcare ecosystem. We focus our science where it can matter most - advancing care in cancers with high unmet need, grounded in a deep understanding of disease biology and deliberate scientific choices that connect discovery to meaningful impact in the real world.The Portfolio Integration Lead (PIL) is a senior role in Oncology Clinical Development, responsible for shaping the advancement of multiple oncology programmes from our portfolio with a focus on particular cancers. Working closely with both the VP and Clinical Development Leads (CDLs) and cross-functional teams across GSK, this role ensures scientific alignment, portfolio coherence, and development excellence across assets. This is a senior individual contributor position that operates across the full breadth of an Oncology portfolio rather than within a single programme, enabling cross-asset integration and strategic alignment across development activities.The PIL applies a disease-level clinical and scientific lens across the portfolio, integrating disease biology, biomarker strategy, and emerging clinical approaches to define what is scientifically feasible and inform development pathways across programmes. This includes bringing clinical context to novel biomarker strategies and trial designs, particularly for early-stage and mechanistically novel assets and across programmes with similar indications.The position is open to candidates from either a medical or non-medical background based on the expertise required to be successful operating at the intersection of oncology disease strategy, clinical development, and portfolio leadership.In This Role You Will:Provide senior scientific partnership to CDLs, particularly in areas such as disease biology, biomarker strategy, and novel treatment combinations development.Ensure consistent cross-programme ways of working to improve development efficiency and execution.Drive cross-programme portfolio working groups and ensure business level alignmentDrive and support clinical trial innovation based on evolving oncology treatment landscape, government regulations, basic/translational science, and emerging technologies (such as AI-enabled tools).Strengthen the scientific and strategic positioning of a pan-asset portfolio across multiple clinical and pre-clinical assets.Drive initiatives that advance data and technology strategies supporting development decision-making.Shape engagement with external experts and governance bodies including advisory boards where relevant.Key ResponsibilitiesPortfolio Strategy & Cross-Program IntegrationShape the advancement of multiple development programs within the oncology portfolio by providing scientific insights across assets, ensuring that agreed disease strategy is implemented consistently across programs.Prepare detailed strategic analyses and portfolio recommendations on behalf of the Disease Area Vice President, enabling effective decision-making at senior leadership and governance levels.Ensure alignment and coordination across Clinical Matrix Teams (CMTs) and relevant cross-functional stakeholders in Research & Development (R&D), Global Medical Affairs (GMA) and Global Product Strategy (GPS).Drive disease-level strategic discussions and portfolio planning, bringing a pan-asset perspective to governance discussions and portfolio prioritization.Serve as a subject matter expert supporting global health authority interactions, regulatory submissions and key development milestones across multiple assets.Partnership with Clinical Development LeadsServe as a scientific thought partner to CDLs across multiple asset programs, shaping key aspects of clinical development strategy for a given tumour types, including:disease biology and translational sciencebiomarker and precision medicine approachescombination strategiesemerging clinical development opportunitiesClinical Development ExcellenceEstablish and champion consistent ways of working across programs to improve efficiency and development quality.Drive innovation in clinical development approaches for a given disease area, including trial design, novel endpoints, and emerging technologies such as AI-enabled analytics where appropriate.External Scientific EngagementMaintain a deep understanding of the evolving tumour disease landscape, standards of care, and emerging science.Shape engagement with external experts through advisory boards.Synthesise portfolio-level external insights to inform and strengthen development strategy across multiple programs.Data & Innovation StrategyDrive initiatives that strengthen the application of data, technology, and analytics in clinical development decision-making for a given tumour type.Champion innovative approaches to clinical trials and portfolio insights, ensuring the tumour portfolio remains at the forefront of emerging capabilities.Basic Qualifications: Bachelor’s / Master’s / Advanced degree in a scientific or medical discipline. Candidates may come from a medical or scientific background; oncology drug development expertise with defined experience is expected.Experience in oncology drug development within pharmaceutical or biotechnology environments, including involvement across multiple programs or assets.Experience of clinical development processes, regulatory pathways, and oncology therapeutic landscapes.Experience in operating structured matrix organizations and demonstrate decision-making and stakeholder engagement at senior organizational levels.Preferred Qualifications:Experience as a Clinical Development Lead, Medical Director, Clinical Scientist Program Lead, or equivalent program leadership role in oncology.Expertise in biomarker development, precision medicine strategies, or combination therapy approaches.Experience engaging with external scientific experts, advisory groups, and Health Authorities.Demonstrated ability to influence senior stakeholders and shape strategic portfolio discussions.Familiarity with clinical trial innovation methods, including AI/ML applications, adaptive trial designs, or real-world evidence integration.Work Arrangement: This role offers a hybrid working model, with a mix of on-site and remote work. Remote or fully home-working arrangements are not available for this role.SkillsClinical Data Interpretation, Clinical Trial Designs, Clinical Trials Monitoring, Digital Fluency, Drug Development, Drug Regulatory Affairs, Evidence Based Decision Making, Executive Presence, Hematology and Oncology, Learning Agility, Matrix Leadership, Real World Evidence (RWE), Scientific Presentations, Strategic DirectionWhy GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at View email address on click.appcast.io where you can also request a call.Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the link where you will find answers to multiple questions we receiveImportant notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at SummaryLocation: UK – London – New Oxford Street; UK - Hertfordshire - Stevenage; Zug House; USA - Pennsylvania - Upper ProvidenceType: Full time