Senior Scientist - AAV (CDMS) - Analytical and Biological Mass Spectrometry (ABMS)

Regeneron Pharmaceutical's Analytical and Biological Mass Spectrometry Group (ABMS), located in Tarrytown, NY, is seeking a highly motivated Sr. Scientist. In this role, you will work in an innovative mass spectrometry (MS) lab and develop LC-MS methods for characterizing biotherapeutic products to support all stages of drug development, from early-stage candidate selections to late-stage regulatory submissions. You will conduct and develop innovative technologies to support a diverse Regeneron's R&D pipeline.

A Typical Day in the Role Might Look Like:

• Design, execute, and clearly communicate analytical characterization for biotherapeutics, including adeno-associated virus (AAV), monoclonal and bispecific antibodies, Fc-fusion proteins, and other modalities, to support drug development.

• Lead and execute characterization activities to evaluate and elucidate critical quality attributes such as charge variants, size variants, and post-translational modifications, with an emphasis on charge detection mass spectrometry (CDMS) and related native-MS approaches.

• Provide analytical support for cross-functional teams, including formulation development, upstream/downstream process development, and manufacturing to solve drug development challenges.

• Proactively advance LC-MS characterization of biotherapeutics by developing innovative techniques that address evolving developmental needs and improve operational efficiency.

• Independently conduct sample preparation and LC-MS analyses in compliance with SOPs, and document experimental procedures and results in electronic laboratory notebook (ELN).

• Author and review regulatory submission documents, including IND, comparability, and BLA reports, and contribute to manuscripts for peer-reviewed publications.

• Represent analytical development on project teams, provide subject matter expertise, and communicate results at internal and external meetings.

This Role Might Be For You If You:

• You thrive in a fast-paced, collaborative environment and consistently deliver results with efficiency and ownership.

• You quickly learn new technologies, tackle complex problems, and have a passion for science.

• You are self-motivated and proactive, prioritizing effectively, and driving work forward with minimal supervision.

To be considered for this role, you must have a BS (10+ years), MS (7+ years) or PhD degree (0-3+ years) in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a closely related field. Experience with charge detection mass spectrometry (CDMS) is strongly preferred. Experience applying LC-MS to extended characterization of AAV and monoclonal antibodies to support product and process development is a plus. Extensive experience with advanced mass spectrometers (Q Exactive Plus, Q Exactive UHMR, Q-TOF, etc.), liquid chromatography, and data processing software (Protein Metrics, Skyline, UniDec etc.) is desired. Experience with experimental design and data analysis (e.g., molecular modeling, graphing, and statistical analysis) is a plus. Please copy and paste the desired job description for this role here. If you need a copy of an existing job description please reach out to TA or work with your HR Business Partner to develop one for a new role.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit For other countries’ specific benefits, please speak to your recruiter.
Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regeneron’s roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regeneron’s on-site policy and expectations for your role and your location.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)

$109,900.00 - $179,300.00