Senior Manager, Principal Software Engineer

Senior Manager, Principal Software Engineer Bristol Myers Squibb | Posted Feb 26 | Full-time | Negotiable | Advanced experience (5‑10 yrs) Working with Us Challenging. Meaningful. Life‑changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high‑achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Position Summary Senior Software Engineer responsible for Pharmacometrics product suite development within the Clinical Pharmacology and Pharmacometrics (CPP) product team. The pharmacometrics product suite supports scientists who work on various pharmacokinetic and pharmacodynamic (PK/PD) modeling methods. In this role, you will have the opportunity to tap into your curiosity and collaborate with some of the most innovative and diverse product team members. You will make an impact by developing software solutions that meet the information needs of the Pharmacometrics scientists. Will be working under the direction of the Product Owner, Clinical Pharmacology and Pharmacometrics. Key Responsibilities Support deployment and operation of AI/ML models, simulation tools, and dashboards for scientific users. Lead the integration of HPC, cloud, and Kubernetes‑based compute environments; optimize parallelization and resource utilization. Collaborate with domain scientists, IT, and other stakeholders to gather requirements and translate scientific workflows into robust technical solutions. Qualifications & Experience – Primary Skills Drive continuous improvement through automation, system upgrades, and stakeholder feedback. Strong software development skills to enable statistical analysis and PK/PD modeling and simulation tools for the Pharmacometrics scientific community. Working knowledge of Unix/Linux Desktop virtual machines, HPC grid (SGE, Slurm) Architect, develop, and maintain scalable software systems and data platforms for clinical pharmacology and pharmacometrics use cases. Mentor engineers and contribute to best practices (CI/CD, DevOps, Agile). Strong documentation and presentation skills. Troubleshoot, monitor, and optimize performance of deployed systems. 5‑7 years hands‑on experience in software engineering, ideally in life sciences or healthcare domains. 5+ years experience developing and managing AWS environments, including Parallel Cluster, Kubernetes, Multiverse. 5+ years’ experience working in a Linux environment. 3+ years of hands‑on experience designing and building data pipelines is required. 3+ years’ experience configuring and developing software leveraging modeling and simulation tools such as R, Python, NONMEM, Monolix, PsN, Pirana, SAS, JupyterHub. 1‑2 years’ experience working with validated systems. Good working experience building and enhancing custom shell and python scripts. Proven track record architecting and delivering production‑grade software and data platforms (preferably supporting scientific research, modeling or analytics). Experience with version control (SVN, GitHub). Familiarity with R package management strategies. Developer with programming skills in Python (primary) and R, integrating with API endpoints in AWS or Google cloud. Experience working with LLM content ingestion, prompt engineering and content generation involving complex tables and images. Experience working of cloud services (AWS, Azure, GCP), HPC, Kubernetes, and parallel/distributed computing. Experience implementing robust access controls, NFS, ACLs, and enterprise authentication. Experience in Shell scripting. Understand all aspects of software development lifecycle. Understand various SDLC methodologies (Agile, Scrum, Waterfall, etc.). Familiarity with R/RStudio/RShiny. Working System Administration knowledge for Linux. Transferring functional to technical requirements. Proficient in MS Office applications including Word, Excel, PowerPoint, and Outlook. Additional Skills Knowledge of vector databases and graph RAG would be a plus. Familiar with Data Bricks and Data Zone. Knowledge of Pharmacometrics modeling or pharmaceutical R&D workflows. Familiar with various IT and PM tools – JIRA, RTC, etc. Agile methodologies. ITIL certified. Proficiency in UI/UX Design and Development, Cloud (AWS/Azure), work with SaaS / PaaS products. Compensation Overview Cambridge Crossing $174,750 – $211,758. The starting compensation range(s) for this role are listed above for a full‑time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. Final, individual compensation will be decided based on demonstrated experience. Benefit Offerings Health Coverage – Medical, pharmacy, dental, and vision care. Wellbeing Support Programs such as BMS Well‑Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP). Financial Well‑being and Protection: 401(k) plan, short‑ and long‑term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support. Paid Time Off US Exempt Employees flexible time off (unlimited, with manager approval, 11 paid national holidays [not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees]). Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non‑Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays. Additional time off may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs, and an annual Global Shutdown between Christmas and New Years Day. Uniquely Interesting Work, Life‑changing Careers With a single vision as inspiring as Transforming patients' lives through science™, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On‑site Protocol BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site‑essential, site‑by‑design, field‑based and remote‑by‑design jobs. Site‑essential roles require 100% of shifts onsite at the assigned facility. Site‑by‑design roles may be eligible for a hybrid work model with at least 50% onsite. For field‑based and remote‑by‑design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS is an essential job function. Supporting People With Disabilities BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer at View email address on click.appcast.io. Visit careers.bms.com/eeo‑accessibility for our complete Equal Employment Opportunity statement. Candidate Rights BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. Data Protection We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at careers.bms.com/fraud‑protection. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at View email address on click.appcast.io. Provide the Job Title and Requisition number so we can review. #J-18808-Ljbffr Scorpion Therapeutics