Research Post Doctoral Fellow

Job Summary and Responsibilities The Ivy Brain Tumor Center at Barrow Neurological Institute is a non-conventional non-profit program offering state-of-the-art clinical trials for patients with the most aggressive form of brain cancer. It is home to the largest collection of Phase 0 trials for brain tumors in the world. Our multidisciplinary team of brain tumor specialists and scientists are accelerating drug discovery and precision medicine in neuro-oncology to identify the most promising first-in-class therapies for brain tumor patients. In this role the Post Doctoral Fellow will design and develop brain targeting therapeutics via rational design and neuro-pharmacokinetic assessment. Principal Duties and Responsibilities: The candidate should have a strong background in chemical/pharmaceutical sciences with a reasonable working knowledge of translational research. Candidates who have experience in Medicinal Organic or Analytical Chemistry and can demonstrate competency in biochemical methods will be preferred. The candidate should be able to work well in highly collaborative environment and have excellent communication skills. Potential areas of application include bioanalysis medicinal chemistry drug development drug pharmacokinetics (PK) organic synthesis method validation biomarker analysis and PK modeling. The candidate is encouraged to apply for internal and external grants. Key responsibilities include

• Rational design and synthesis of novel brain-targeting therapeutic agents.
• Characterization of novel molecules using necessary physicochemical means including NMR MS UV-vis etc.
• Development of analytical methods for determination of newly synthesized molecules various drugs drug candidates metabolites and biomarkers in various biological matrices employing LC-MS/MS techniques.
• Performing biochemical characterization of various molecules.
• Manuscript preparation and publishing.
• Supervision and training of laboratory supporting research staff.
• Preparation and delivery of research presentations at local meetings national and international conferences.
• General operation maintenance and troubleshooting of laboratory equipment.
• Preparation and maintenance of required laboratory safety documentation and adherence to the guidelines and regulations.

Preferred Qualifications:

• Experience in organic synthesis bioanalysis medicinal or pharmaceutical chemistry areas.
• Experience with rational drug design and development physicochemical characterization.
• Experience with UHPLC or LCMS-based assay development.
• Good organizational and analytical skills.
• Ability to work independently and cohesively as part of a team.

Additional Requirements Recommendation letters Education Ph.D. or equivalent degree (MD DVM PharmD etc.) in Pharmaceutical Sciences Chemistry Biochemistry Medical Sciences or in related disciplines. Job Requirements Required Ph.D., post-baccalaureate M.D. or D.Sc. degree or equivalent in a relevant field of endeavor and Laboratory or clinical research at the post-baccalaureate level with an interest in a faculty member's line of study, upon hire Preferred Doctorate Of Science in a relevant field of endeavor and beyond minimum required, experience writing research reports concerning own work and familiarity with a biomedical discipline Where You'll Work Hello humankindness Located conveniently in the heart of Phoenix, Arizona, St. Joseph's Hospital and Medical Center is a 571-bed, not-for-profit hospital that provides a wide range of health, social and support services. Founded in 1895 by the Sisters of Mercy, St. Joseph's was the first hospital in the Phoenix area. More than 125 years later, St. Joseph's remains dedicated to its mission of caring for the poor and underserved. We are extremely proud to be a nationally recognized center for quality quaternary care, medical education and research. St. Joseph's includes the internationally renowned Barrow Neurological Institute, Norton Thoracic Institute, Cancer Center at St. Joseph's, Ivy Brain Tumor Center, and St. Joseph's Level I Trauma Center (which is verified by the American College of Surgeons). The hospital is also a respected center for high-risk obstetrics, neuro-rehabilitation, orthopedics, and other medical services. St. Joseph’s is considered a sought-after destination hospital for treating the most complex cases from throughout the world. Every day, approximately 20 percent of the hospital’s patients have traveled from outside of Arizona and the United States to seek treatment at St. Joseph’s. U.S News & World Report routinely ranks St. Joseph's among the top hospitals in the United States for neurology and neurosurgery. In addition, St. Joseph's boasts the Creighton University School of Medicine at St. Joseph's, and a strategic alliance with Phoenix Children's Hospital. St. Joseph's is consistently named an outstanding place to work and one of Arizona's healthiest employers. Come grow your career with one of Arizona's Most Admired Companies. Look for us on Facebook and follow us on Twitter. For the health of our community ... we are proud to be a tobacco-free campus. #J-18808-Ljbffr CommonSpirit Health