Part Time Physician Principal Investigator

Job Description

Job Description

Principal Investigator (Family Practice or Internal Medicine MD/DO)

Kelly Science and Clinical is currently hiring a Principal Investigator to work part-time, onsite in Houston TX for one of our clients who is dedicated to advancing medical innovation and healing technology through groundbreaking research.

• Location : On-site in Houston TX  (some remote chart review/sponsor calls as studies permit)
• Hours : 5 - 15 hours/week depending on the study needs  
  • The exact hours will vary based on the needs of the clinical trial study, offering both adaptability and the opportunity to work on a dynamic and engaging project
• Pay : Depends on industry experience. Range of $120 - $150.00 / 1099 hourly 
• Duration : Long term, no end date with potential to grow with the team as well as add additional hours if warranted 

About the Role:
We’re seeking Family Medicine or Internal Medicine Physicians to serve as Principal Investigators (PIs) at our Houston, TX research site. This position is ideal for physicians seeking a slower pace of work and very flexible, part-time hours (approximately 5–15 hours/week depending on study needs). Comprehensive PI onboarding and ongoing support are provided. You’ll provide medical oversight for clinical trials, ensure participant safety, and help generate high-quality data—without the heavy demands of a traditional clinic schedule. We’re looking for amazing candidates with clinical trial experience, as well as a Schedule I or II license (preferred). 

Key Responsibilities:
•    Serve as the study physician for assigned trials; ensure participant safety and ethical conduct.
•    Review and confirm participant eligibility; oversee screening outcomes, AEs/SAEs, and retention trends.
•    Perform/oversees study-specific medical assessments (histories/physicals, concomitant meds, endpoint review).
•    Provide medical oversight to site staff (Sub-Investigators, CRCs, RNs, lab staff); be available for consults and safety questions.
•    Collaborate with IRBs, sponsors, and CROs; join SIVs, monitoring visits, and close-out activities as needed.
•    Ensure compliance with protocols, site SOPs, ICH-GCP, FDA/21 CFR, and Arizona or Texas state requirements (as applicable).
•    Review clinical data (labs, ECGs, vitals) and support timely safety reporting and documentation.
•    Contribute to high-quality source documentation, query resolution, and continuous improvement of site processes.

Minimum Qualifications:
•    MD or DO (Family or Internal Medicine).
•    Active, unrestricted TX Medical Board license, as applicable.
•    Experience in clinical research and comfort reviewing structured clinical data. Prior experience as a PI or Sub-Investigator is required. 
•    Strong documentation, communication, and confidentiality practices (HIPAA/PHI).
•    Familiarity with ICH-GCP and FDA regulations (21 CFR Parts 50, 54, 56, 312, 812).
•    Board certification in Family or Internal Medicine or relevant therapeutic area focus 

Preferred Qualifications:
•    DEA registration – Schedule I or II license, or are willing to obtain this license. 

As part of our promise to talent, Kelly supports those who work with us through a variety of benefits, perks, and work-related resources. Kelly offers eligible employees voluntary benefit plans including medical, dental, vision, telemedicine, term life, whole life, accident insurance, critical illness, a legal plan, and short-term disability. As a Kelly employee, you will have access to a retirement savings plan, service bonus and holiday pay plans (earn up to eight paid holidays per benefit year), and a transit spending account. In addition, employees are entitled to earn paid sick leave under the applicable state or local plan. Click here for more information on benefits and perks that may be available to you as a member of the Kelly Talent Community.

Why Kelly® Science & Clinical?

Kelly Science & Clinical is your connection to premier scientific and clinical companies looking to hire industry experts just like you. Our team creates expert talent solutions to solve the world’s most critical challenges. Every day, we match science professionals with dream jobs that fit their skills, interests, and career goals-it’s the way we think job searching should be. Nearly 100 percent of our science recruiters have a professional background and education in science, so we know a thing or two about the science market and how to get your expertise noticed.

About Kelly

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