Process Dev Engineering Senior Scientist, Media Development

Job Description General Summary: Cell, gene and biologic therapies are rapidly growing parts of Vertex Pharmaceuticals, where research, development, and clinical manufacturing are highly integrated together at our new R&D site in Boston Seaport. Vertex is seeking a talented individual to join our Process Development team to support media development and optimization efforts. The focus of this position is to support advancement of the innovative stem cell culture medium development and optimization for cell and gene therapy applications. This position will collaborate with cross functional teams to advance media optimizations to enable process scaling, cost of goods reduction, and process robustness improvement through fundamental process understanding. The ideal candidate has deep expertise in media development and optimization, fundamental cell culture process understanding, thrive in a fast-paced environment and proven ability to perform under pressure. The position will be based in Boston, MA. Key Duties and Responsibilities: Develop robust and cost-effective cell culture media for commercial scale manufacturing. Define and implement technical roadmaps for media development and optimization, ensuring alignment with business priorities and leadership strategy. Troubleshoot complex raw material sourcing and control challenges, with a strong understanding of GMP, regulatory, and quality requirements. Develop and optimize high-throughput, small-scale media screening toolboxes to enhance media development processes. Stay up to date with emerging analytical tools, omics technologies and scientific advancements to drive hypothesis guided media optimization. Generate and review technical reports, regulatory filings, source documents, patents and external publications. Support media preparation protocol transfer to pilot team and support GMP manufacturing tech transfer. Foster strong partnerships with internal and external stakeholders, proactively managing relationships to ensure alignment and efficient execution. Potential of managing or mentoring a small group of junior level employees. Lead by example, work closely with the team in the lab and conduct hands-on experiments. Foster a culture of innovation and continuous improvement. Knowledge and Skills: Strong fundamental knowledge in cell culture metabolism and biological pathways, and extensive experience of medium development (stem cell culture experience is preferred) In-depth understanding and extensive experience of cell culture process development, perfusion process development, and bioreactors across scales. Experience with high throughput and automated cell culture platforms is highly preferred. Extensive knowledge and experience on raw material control and sourcing considerations. Solid knowledge and experience with statistical principles and design of experiments (DOE). Must have a working knowledge of cGMP. Excellent verbal and written communication skills. Ability to handle multiple tasks while meeting timelines and adapting to changing priorities. Strong people skills and ability to work with diverse team dynamics, and potential in the future to manage a team. Excellent organizational skills and high attention to detail. Strong people skills and ability to work with diverse teams Education and Experience: Degree in relevant engineering or scientific discipline (e.g., chemical or biochemical engineering, natural or life sciences). PhD with 2-5 years of relevant industry work experience, or a MS with 6-9 years of relevant industry experience, or a BS with 8-11 years of industry experience. Participation in weekend work rotation with the broader team required. Pay Range: $123,200 - $184,800 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at View email address on click.appcast.io Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.