Senior Director, Global Medical Affairs

Job ID: R-111184Company: LillyLocation: Indianapolis, Indiana, United States of AmericaJob Type: Full TimeCategory: MedicalPosted Date: 2026-09-01At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. Centessa Pharmaceuticals, a wholly subsidiary of Eli Lilly and Company is advancing a portfolio of high conviction programs with strong biological validation.  Our asset-centric model offers a unique R&D logic that has been applied by single asset companies to improve productivity. This operating model has minimal centralized infrastructure, reduced hierarchy, and exclusive focus on data driven capital allocation. Our teams are uniquely incentivized to expeditiously interrogate key scientific hypotheses. We believe the asset-centric model can lead to improved success rates for programs with greater speed and modest costs. Description of RoleThe Senior Director, Global Medical Affairs, will serve as the Global Medical Affairs Lead for Centessa's lead orexin receptor 2 agonist program. This strategic leadership role is responsible for developing and executing the global medical strategy across the product lifecycle, with a primary focus on launch readiness, scientific leadership, evidence generation, external engagement, and cross-functional partnership.The successful candidate will have demonstrated experience leading global medical affairs activities for one or more successful product launches and possess a strong track record of partnering with commercial, market access, HEOR, clinical development, regulatory affairs, patient advocacy and regional medical teams to deliver integrated launch strategies. The individual will serve as the medical voice of the asset, ensuring that scientific evidence, stakeholder insights, and patient needs are incorporated into key business decisions.This role reports to the Head of Medical Affairs and will partner closely with senior leadership across the organization.Key ResponsibilitiesGlobal Medical Strategy & LeadershipLead the global medical affairs strategy and tactical execution plan for cleminorextonServe as the Global Medical Affairs Lead and core member of the cross-functional asset teamEnsure alignment of medical strategy with corporate objectives, clinical development milestones, and commercialization plansEstablish long-range medical affairs planning to support regulatory approvals, launch readiness, and lifecycle managementIdentify emerging scientific opportunities, evidence gaps, and stakeholder needs to inform future developmentGlobal Launch ExcellenceLead medical launch preparedness activities across major global marketsPartner with commercial, market access, HEOR, regulatory affairs, and regional medical teams to develop integrated launch strategiesCollaborate with medical affairs colleagues to ensure deliverables are aligned with strategy and launch timelines, including scientific platforms, training content, medical information resources, publications, congress activities, and insights generationSupport pre-launch and launch planning activities, including collaborating with HEOR and market access for global payer engagement strategies and value communicationExternal Scientific EngagementBuild and maintain relationships with global key opinion leaders, investigators, professional societies, and patient advocacy organizations.Lead scientific advisory boards, expert consultations, and other insight-gathering initiatives.Represent Centessa at major scientific congresses and industry meetings.Serve as a credible scientific ambassador and subject matter expert for orexin biology and sleep-wake disorders.Cross-Functional PartnershipAct as a strategic partner to commercial, market access, HEOR, regulatory, clinical development, patient advocacy, and corporate affairsContribute medical expertise to brand strategy, payer engagement, disease-state education, and scientific communication initiativesStrategic partner for development of scientific platforms, publication strategies, educational programs, and medical trainingProvide medical review and guidance for externally facing scientific materials in compliance with applicable regulations and company policiesQualificationsRequiredAdvanced scientific or clinical degree (MD, PharmD, or PhD)Minimum 10 years of Medical Affairs leadership experience with 5 years global experience preferredExperience in neuroscience, sleep medicine, neurology, psychiatry, or rare diseaseDemonstrated experience leading at least one successful global product launch (North America, Europe, and Asia-Pacific markets highly preferred)Experience serving as a global medical lead for late-stage development or commercial productsStrong understanding of global medical affairs, evidence generation, payer evidence requirements, and commercialization readinessProven ability to drive strategy in a matrix environmentProven track record of collaborating closely with commercial, market access, HEOR, regulatory affairs, and clinical development organizationsExceptional communication, presentation, and stakeholder management skillsWork LocationThe Sr. Director, Global Medical Affairs role is remote, based in the US, with occasional travel (~20%).Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form () for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (View email address on click.appcast.io), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is$177,000 - $338,800Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.#WeAreLillySkillsmedical affairs leadershipglobal medical strategyproduct launch managementevidence generationregulatory affairsscientific advisorystakeholder engagementcross-functional collaborationpayer engagementscientific communicationmedical reviewclinical developmentmarket accessscientific platform developmentpublication strategymedical trainingsleep medicineneurosciencepsychiatryrare diseasematrix managementpresentation skillsstakeholder management