Principal Scientist / Senior Research Scientist / Scientific Operations Principal - Histopathology &

Job Description

Principal Scientist – Histopathology & Translational Biomarkers 

• Location : Bay Area, CA
• Compensation: $150,000–$200,000 annually
• Employment: Full-Time, Permanent

We are seeking an experienced Principal Scientist to provide scientific leadership across histopathology, translational biomarker, digital pathology, and tissue-based research programs. This is an excellent opportunity for a Ph.D.-level scientist who enjoys solving complex scientific problems, designing and troubleshooting studies, interpreting tissue-based data, and serving as a technical resource for both internal teams and biopharma customers. This is not a traditional people-management position. The Principal Scientist will lead through scientific expertise, technical guidance, and project coordination while remaining closely involved in the science.

Responsibilities
- Provide scientific leadership for histopathology, translational biomarker, and tissue-based research programs
- Support development, optimization, and validation of IHC, IF, and other tissue-based assays
- Guide experimental design, controls, study feasibility, troubleshooting, and scientific interpretation
- Conduct literature research and translate findings into practical study recommendations
- Support digital pathology, whole-slide imaging, and quantitative image-analysis workflows
- Interpret biomarker, histopathology, and image-analysis results
- Participate in technical scoping, study planning, and scientific discussions with biopharma customers
- Provide technical guidance and mentorship to scientists and cross-functional project teams
- Support SOP development, scientific best practices, quality systems, and process improvements

Requirements
- Ph.D. in Pathology, Biomedical Sciences, Biology, Bioengineering, or a related scientific discipline
- 3+ years of experience in histopathology, translational biomarkers, or closely related tissue-based research
- Strong understanding of tissue-based assays, pathology techniques, biomarker analysis, and scientific interpretation
- Experience with IHC, IF, assay development, optimization, and/or validation
- Strong experimental design and scientific troubleshooting skills
- Experience leading scientific projects or providing technical leadership to other scientists
- Strong scientific communication and stakeholder-management skills

Preferred Experience
- Digital pathology and whole-slide imaging
- Visiopharm, HALO, QuPath, Aperio, or comparable image-analysis platforms
- Multiplex imaging, spatial biology, biomarker scoring, or cell phenotyping
- Biotechnology, pharmaceutical, CRO, or translational research environment
- CAP, CLIA, GLP, or other regulated laboratory experience
- Customer-facing scientific or technical support

If you are a Ph.D.-level scientist with a strong background in histopathology, tissue biomarkers, and translational research and are interested in taking on greater scientific leadership while remaining close to the science, we encourage you to apply.

Apply Today!

Ready to take the next step in your career? We'd love to hear from you!

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