Senior Scientist, Bioconjugation Chemistry, ADC Technology

Reference: 629451Posted: 2026-09-03Location: Boston, MassachusettsCompany: Planet Pharma GroupContact: ApplicationsEmail: View email address on click.appcast.io are seeking a highly motivated Senior Scientist to join our growing Chemistry and Bioconjugation Drug Discovery team. The ideal candidate will have expertise in bioconjugation chemistry, linker technologies, and conditional release, with a strong foundation in organic chemistry, chemical biology, or biochemistry. This hands-on laboratory role will support the design, synthesis, conjugation, purification, and characterization of next-generation antibody-drug conjugates (ADCs) and other targeted biotherapeutics. The successful candidate will collaborate closely with multidisciplinary teams to advance discovery programs and contribute to the development of innovative conjugation technologies.Key ResponsibilitiesDesign, execute, and optimize bioconjugation experiments to support discovery programs and platform development.Develop, optimize, and scale bioconjugation reactions, purification processes, and analytical characterization methods for ADCs and other conjugate biotherapeutics.Purify bioconjugates using techniques including size exclusion chromatography (SEC), affinity chromatography, ultrafiltration/diafiltration (UF/DF), and automated chromatography systems (e.g., AKTA FPLC).Characterize bioconjugates using analytical techniques including HPLC, LC-MS, gel electrophoresis, UV-Vis spectroscopy, and microfluidic platforms (e.g., CE-SDS and iCIEF).Interpret analytical data, troubleshoot reactions and purification processes, and recommend technical solutions to advance project objectives.Contribute to project strategy by providing scientific input and supporting the development of next-generation conjugation technologies.Present research findings and project updates to internal teams and external collaborators.Maintain accurate experimental records using electronic laboratory notebooks (ELNs) and contribute to technical reports and project documentation.Support laboratory operations by maintaining shared equipment, improving workflows, and promoting an organized, efficient laboratory environment.QualificationsPh.D. in Organic Chemistry, Medicinal Chemistry, Chemical Biology, Biochemistry, or a related field with a minimum of 5 years of relevant bioconjugation experience; or M.S. with 8+ years; or B.S. with 11+ years of relevant industry experience.Industry experience in bioconjugation and antibody drug conjugates within the biopharmaceutical or pharmaceutical industry.Demonstrated expertise in bioconjugation technologies, linker chemistry, and conditional release methodologies.Experience with preparative purification of proteins and bioconjugates using chromatographic techniques.Hands-on experience with analytical characterization methods, including HPLC, LC-MS, UV-Vis spectroscopy, electrophoresis, and related protein analytical techniques.Strong analytical and problem-solving skills with the ability to troubleshoot experimental challenges and develop practical solutions.Scientific curiosity and enthusiasm for developing and implementing innovative bioconjugation technologies.Excellent written and verbal communication skills, with the ability to present scientific findings to multidisciplinary teams.Strong organizational and time-management skills with the ability to manage multiple projects in a fast-paced environment.Demonstrated ability to work independently while collaborating effectively within cross-functional teams.