Principal Software Engineer

Career Category Information Systems Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Principal Software Engineer What you will do Let’s do this. Let’s change the world. In this vital role you will play a pivotal role in building and scaling our machine learning models from development to production. Your expertise in both machine learning and operations will be essential in creating efficient and reliable ML pipelines. A background in data engineering, including experience with data pipelines and distributed data processing, is a strong plus. Roles & Responsibilities: Lead the end-to-end design, development, and delivery of machine learning and Generative AI (GenAI) solutions, from problem framing to production deployment and business impact realization. Act as the technical owner for large-scale ML/GenAI initiatives, driving architecture decisions, scalability, reliability, and long-term maintainability. Design and implement advanced agentic AI systems, including multi-agent architectures, reasoning workflows, tool integration, and autonomous decision-making systems. Define and institutionalize evaluation, validation, and governance frameworks for ML/GenAI systems, including model performance, prompt evaluation, safety guardrails, hallucination mitigation, and compliance. Partner directly with business stakeholders and product leaders to understand objectives, translate them into AI/ML solutions, and ensure measurable value delivery. Establish and enforce best practices in MLOps, LLMOps, and DevOps, including CI/CD, monitoring, observability, reproducibility, and cost optimization. Architect and oversee scalable cloud-based ML/GenAI platforms leveraging AWS, GCP, or Azure. Drive experimentation strategy, including A/B testing, prompt optimization, and iterative improvement of models and agent workflows. Provide technical leadership and mentorship to L4 and L5 engineers, including design reviews, code reviews, and career guidance. Lead cross-functional collaboration across data science, engineering, product, and business teams to deliver integrated AI solutions. Stay at the forefront of advancements in machine learning, Generative AI, and agentic systems, and drive adoption of new technologies and approaches. Design, develop, and implement robust data architectures and platforms to support ML Operation. Ensuring data integrity, accuracy, and consistency through rigorous quality checks and monitoring. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a Software Engineer with these qualifications. Doctorate degree and 2 years of experience OR Master’s degree and 4 years of experience OR Bachelor’s degree and 6 years of experience OR Associate’s degree and 10 years of experience OR High school diploma / GED and 12 years of experience Deep expertise in machine learning, deep learning, and Generative AI (LLMs, transformers, embeddings, fine-tuning techniques). Proven track record of leading and delivering production-grade ML/GenAI systems end-to-end with measurable business impact with strong experience in designing scalable system architectures for ML and GenAI, including distributed systems and high-throughput pipelines. Expertise in MLOps/LLMOps ecosystems (MLflow, Kubeflow, Airflow, CI/CD, Docker, Kubernetes). Strong system design, architecture, and problem-solving skills with the ability to operate independently and lead large initiatives. Demonstrated proficiency in leveraging cloud platforms (AWS, Azure, GCP) for data engineering solutions. Strong understanding of cloud architecture principles and cost optimization strategies.  Proven ability to mentor and guide junior and mid-level engineers (L4/L5). Good-to-Have Skills: Degree in computer science, Statistics, and Data Science preferred. Master’s degree and 6+ years experience Or Bachelor’s degree and 8+ years’ experience Cloud Computing certificate preferred  Experience with big data ecosystems (Spark, Hadoop) and large-scale data processing.  Strong background in data engineering and building scalable data platforms. Advanced proficiency in Python and modern ML/AI frameworks (PyTorch, TensorFlow, Hugging Face, LangChain or similar). Experience designing robust evaluation and validation systems, including automated evals, human-in-the-loop, safety testing, and monitoring frameworks. Extensive experience with RAG architectures, vector databases, and knowledge-grounded systems. Strong understanding of agentic AI frameworks, including orchestration, planning, memory, and tool use.  Knowledge of advanced statistical modeling, experimentation design, and causal inference.  Experience with NLP, semantic search, embeddings, and vector search systems.  Familiarity with Responsible AI practices, including fairness, explainability, governance, and regulatory considerations.  Experience with cloud-native AI/ML services (AWS, Azure, GCP) and cost/performance optimization.  Experience with Databricks platform for enterprise-scale ML and GenAI workloads.  Exposure to advanced evaluation techniques, including red-teaming, adversarial testing, and synthetic data generation.  Experienced with data modeling and performance tuning for both OLAP and OLTP databases  Experienced with Apache Spark, Apache Airflow and Databricks platform What you can expect of us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. Sponsorship Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. . Salary Range 157,020.50USD -212,439.50 USD Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. For more information, visit and follow us on