Senior Software Engineer, Voice AI

Role Description

This is a high-autonomy, high-agency position for a voice AI engineer who thrives at the intersection of real-time systems, conversational AI, and healthcare. You'll own the architecture and delivery of Natera's Voice AI platform — a production system handling thousands of patient calls daily that provides automated test status, identity verification, billing support, and intelligent routing to human agents.

You'll work across the full voice AI stack: telephony, speech-to-text, LLM orchestration, text-to-speech, and analytics — building agentic conversational systems that directly improve patient access to their genetic testing results. This role requires deep understanding of the intricacies unique to voice AI: real-time audio streaming, turn-taking, interruption handling, latency optimization, and the orchestration challenges that distinguish voice from text-based AI systems.

Your work will span two critical domains:

1. Voice AI Platform Engineering

Design, build, and operate Natera's production voice AI system. This includes multi-agent orchestration, real-time WebSocket audio pipelines, telephony integration, and the voice-specific challenges of latency management, VAD tuning, barge-in handling, and ASR accuracy for medical terminology.

2. Agentic Conversational Architecture

Architect and implement autonomous agent workflows that handle complex patient interactions end-to-end — identity verification, OTP validation, personalized test status delivery, billing inquiries, and intelligent escalation. You'll design tool-calling patterns, agent handoff logic, state management across conversation turns, and the analytics infrastructure needed to measure and improve call efficacy.

What You'll Do

• Own the end-to-end voice AI architecture — from Twilio media streams through LLM orchestration to TTS output and call disposition

• Design and implement multi-agent systems using tool calling, agent handoffs, and shared conversation state for complex patient workflows

• Build and optimize real-time audio pipelines — WebSocket streaming, codec handling (mulaw/PCM), VAD configuration, and interruption management

• Architect analytics and observability infrastructure for voice-specific metrics: per-segment latency (STT/LLM/TTS), call efficacy, disposition accuracy, and ASR error rates

• Solve voice-specific challenges: turn-taking timing, silence detection thresholds, barge-in recovery, medical term recognition, and end-to-end latency optimization

• Integrate voice agents with internal services via secure authenticated APIs

• Drive platform reliability — eliminate single points of failure, implement multi-provider LLM failover, and design graceful degradation paths

• Collaborate with product and clinical operations to improve self-serve efficacy rates and reduce call escalations

• Mentor team members on voice AI best practices and contribute to architectural decisions

What We're Looking For

• 5+ years of software engineering experience, with at least 2 years building production voice AI or conversational AI systems

• Deep experience with voice AI pipelines — you understand the end-to-end flow from telephony through STT, LLM processing, TTS, and back to the caller, and you've solved real problems at each stage

• Production experience with agentic architectures — multi-agent orchestration, tool calling, agent handoffs, memory/state management, and LLM-driven decision making in real-time conversation contexts

• Strong understanding of voice-specific challenges: VAD tuning, turn-taking, interruption/barge-in handling, latency budgets, audio codec management, and the differences between voice and text-based AI UX

• Hands-on experience with telephony systems — Twilio (media streams, SIP, IVR), or equivalent platforms with WebSocket-based audio streaming

• Proficiency in TypeScript/Node.js with strong async programming patterns; experience with NestJS or similar frameworks

• Experience with STT/TTS providers (Deepgram, OpenAI, ElevenLabs, Azure Speech) and understanding of ASR accuracy challenges (domain-specific vocabulary, noise handling)

• Production experience with LLM APIs — OpenAI (especially Realtime API), Anthropic Claude, or equivalent; prompt engineering for conversational agents

• High agency and autonomy — you don't wait for permission, detailed specs, or hand-holding. You unblock yourself, seek out the highest-impact work, and drive it to completion

• Excellent communication — you can translate complex voice AI architecture decisions for product and clinical stakeholders

Preferred

• Experience in healthcare, biotech, or regulated environments (HIPAA, PHI handling, zero-retention architectures, BAA compliance)

• AWS infrastructure experience — ECS Fargate, Lambda, DynamoDB, Bedrock, Kafka/MSK, API Gateway, CDK

• Background in real-time systems: WebSocket lifecycle management, connection resilience, streaming protocols

• Experience building analytics pipelines for voice/conversational metrics (call efficacy, disposition tracking, latency observability)

• Familiarity with RAG architectures (vector stores, embedding models, chunking strategies) for knowledge-grounded voice agents

• Track record of migrating or evaluating vendor platforms while maintaining production uptime

• Experience with Datadog APM, LLM Observability, or equivalent monitoring for AI systems

• Prior experience in a high-growth startup or zero-to-one product environment

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit .

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents. 

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Please be advised that Natera will reach out to candidates with a @ natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

For more information:
- BBB announcement on job scams  
- FBI Cyber Crime resource page