Senior Biophysicist (Structural Biology)

About the Role Our client, a renowned research organization focused on molecular mechanisms of disease, is seeking a highly skilled Senior Biophysicist specializing in Structural Biology to join their advanced laboratory in Upington, Northern Cape . This role is central to elucidating the three-dimensional structures of biological macromolecules and understanding their functional implications. You will lead projects involving protein expression, purification, crystallization, and structural determination using techniques such as X-ray crystallography, cryo-EM, or NMR spectroscopy. We are seeking an expert biophysicist with a proven ability to solve complex structural biology challenges and contribute to drug discovery and fundamental biological research. Key Responsibilities Lead research projects aimed at determining the structures of key biological macromolecules (proteins, nucleic acids, complexes). Optimize protocols for protein expression, purification, and characterization. Perform structural determination using advanced biophysical techniques (e.g., X-ray crystallography, cryo-EM, NMR). Analyze structural data, build models, and interpret the functional significance of molecular structures. Collaborate with biochemists, molecular biologists, and computational scientists to integrate structural findings. Develop and implement novel structural biology methodologies. Maintain and operate state-of-the-art biophysical instrumentation. Mentor junior scientists and technicians in structural biology techniques. Prepare scientific manuscripts for publication in high-impact journals. Present research findings at scientific conferences and symposia. Requirements Ph.D. in Biophysics, Structural Biology, Biochemistry, or a related field. Minimum of 5-7 years of post-doctoral or industry research experience in structural biology. Extensive hands-on experience with at least one major structural determination technique (X-ray crystallography, cryo-EM, or NMR). Proven expertise in protein expression, purification, and characterization. Proficiency in structural data analysis and molecular modeling software. Strong understanding of the principles of protein structure-function relationships. Excellent problem-solving skills and attention to detail. Strong written and verbal communication skills, with the ability to effectively present complex scientific data. Ability to work independently and as part of a collaborative research team. Experience with computational methods in structural biology is a plus. Benefits Our client offers a competitive salary and a comprehensive benefits package, including health, dental, and retirement plans. We provide excellent opportunities for professional development, including funding for specialized training, workshops, and attendance at international conferences. Employees will have access to cutting-edge structural biology facilities and advanced instrumentation. This role in Upington, Northern Cape , offers a unique opportunity to contribute to fundamental biological discoveries and therapeutic development in a stimulating research environment. We are committed to fostering scientific innovation and career growth. #J-18808-Ljbffr