Senior HR Business Partner

At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives.

We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting-edge molecular science and AI, we ask ourselves every day: “What would I do if this patient were my mom?” That question drives everything we do.

But our mission doesn’t stop with cancer. We're pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose.

Join us in our mission to improve the human condition across multiple diseases. If you're passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins.

Position Summary

The Senior Human Resources Business Partner serves as a strategic leader and trusted advisor to senior leadership at Caris Life Sciences, driving enterprise-level people strategies that enable business growth, innovation, and organizational effectiveness. This role partners closely with executive stakeholders to design and implement workforce strategies, organizational structures, and leadership initiatives that support Caris’ mission in precision medicine and oncology.

Job Responsibilities

• Serve as a strategic advisor to Vice President and senior executive leaders, aligning people strategy with business objectives and growth priorities.

• Lead organizational design initiatives, including structuring teams, optimizing spans and layers, and enabling scalable growth across functions.

• Develop and drive workforce planning strategies aligned with commercial expansion, clinical operations, and innovation priorities.

• Lead enterprise talent management processes, including succession planning, leadership development, and talent segmentation.

• Provide executive coaching to senior leaders on leadership effectiveness, organizational health, and team performance.

• Utilize HR analytics and business data to generate insights, forecast workforce needs, and influence executive decision-making.

• Lead complex management initiatives, including organizational transformations, restructures, and business scaling efforts.

• Partner with HR Centers of Excellence to design and implement enterprise HR solutions across compensation, talent acquisition, and development.

• Oversee and manage high-risk employee relations issues in partnership with Legal and Compliance to mitigate organizational risk.

• Drive culture and engagement strategies that reinforce a high-performance, mission-driven environment.

• Influence and shape HR strategy by providing feedback and direction to HR leadership and COE partners.

• Mentor and provide guidance to HRBP team members, helping to elevate overall HR capability.

Required Qualifications

• Bachelor’s degree in human resources, Business Administration, or related field.

• 5+ years of progressive Human Resources experience, including strategic HRBP experience.

• Demonstrated experience partnering with senior executives and leading organizational change initiatives.

• Proven ability to develop and implement workforce strategies aligned to business outcomes.

• Strong business acumen, with experience supporting commercial, clinical, or operational functions.

• Experience in organizational design, talent strategy, and leadership development.

• Exceptional communication, consulting, and influencing skills.

• Proficient in Microsoft Office Suite, specifically Word, Excel, Outlook, and general working knowledge of Internet for business use.

Preferred Qualifications

• Experience in life sciences, diagnostics, biotechnology, or healthcare industries.

• Experience supporting high-growth or rapidly scaling organizations.

• Master’s degree or MBA.

• HR certification (SHRM-SCP, SPHR).

• Cannot reject candidate based on preferred qualifications.

Physical Demands

• Ability to remain in a stationary position for extended periods of time.

• Ability to operate a computer and other office equipment.

• Occasional ability to move or lift up to 15 pounds.

Training

• All job specific, safety, and compliance training are assigned based on the job functions associated with this employee.

Other

• This position requires periodic travel to support business leaders and enterprise initiatives.

• At times may require work outside standard business hours to support executive stakeholders and business needs.

Conditions of Employment: Individual must successfully complete pre-employment process, which includes criminal background check, drug screening, credit check ( applicable for certain positions) and reference verification.

This job description reflects management’s assignment of essential functions. Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.

Caris Life Sciences is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender, gender identity, sexual orientation, age, status as a protected veteran, among other things, or status as a qualified individual with disability.

Caris Life Sciences is a leading innovator in molecular science and artificial intelligence focused on fulfilling the promise of precision medicine through quality and innovation.

Caris is committed to quality and excellence at our state-of-the-art laboratories. Learn more about our tissue lab and the advanced technologies that are helping improve the lives of cancer patients.