Senior Research Scientist, Target Identification & Validation Translational Immunology

Key Duties And Responsibilities Design, execute, and interpret experiments to identify and validate novel therapeutic targets relevant to autoimmune and inflammatory diseases Develop and optimize disease‑relevant in vitro and ex vivo assay systems using primary human immune cells and patient‑derived samples to evaluate target biology and therapeutic potential Integrate multi‑dimensional datasets including genomic, transcriptomic, proteomic, and functional data to generate and refine target hypotheses Collaborate with data and computational sciences colleagues to leverage large‑scale human datasets for target discovery and prioritization Contribute to the design and execution of in vivo studies to assess target relevance and therapeutic mechanisms in preclinical models Present scientific findings and strategic recommendations to cross‑functional project teams, senior leadership, and external collaborators with clarity and scientific rigor Evaluate and implement emerging technologies and experimental platforms to advance target identification and validation capabilities Collaborate closely with immune cell profiling, clinical biomarker, and drug discovery teams to support program progressionMaintain thorough and accurate documentation in electronic laboratory notebooks and contribute to internal knowledge‑sharing Stay current with scientific literature to inform research strategy Perform other duties as assigned Knowledge And Skills Strong expertise in immunology and immune cell biology Proven experience isolating, culturing, and functionally characterizing primary human immune cells from peripheral blood and tissues Deep proficiency in multi‑parameter flow cytometry (panel design, acquisition, data analysis) Hands‑on experience with ELISA, MSD, qPCR, Western blotting, and cell‑based functional assays Familiarity with CRISPR‑based gene editing for target validation Working knowledge of single‑cell technologies, multi‑omics, and high‑dimensional data analysis Basic computational skills (data visualization and statistical analysis) Ability to design rigorous experiments and draw clear scientific conclusions Excellent written and oral communication skills Strong collaboration skills in cross‑functional, multi‑site teams Scientific creativity with attention to detail, data quality, and reproducibility Education And Experience Ph.D. (or equivalent) in immunology/molecular biology/cell biology/biochemistry or related + 2-5 years post‑doctoral experience, OR Master’s (or equivalent) in related field + 5+ years relevant experience, OR Bachelor’s (or equivalent) in related field + 8+ years relevant experience Benefits Annual bonus and annual equity awards Medical, dental, and vision benefits; paid time off (incl. week‑long company shutdown in Summer and Winter); educational assistance (incl. student loan repayment); commuting subsidy; matching charitable donations; 401(k) Application Instructions For accommodation requests related to the hiring process or essential job functions: View email address on click.appcast.io #J-18808-Ljbffr