Principal Research Scientist - Cancer Biology

Position Overview

We are looking for a highly motivated PhD-level scientist with strong laboratory expertise to contribute to a priority research initiative focused on understanding cancer biology mechanisms through advanced cellular and molecular approaches. This role demands technical depth, critical thinking, and a hands-on approach to experimental science.

The individual in this position will collaborate with a cross-functional team to investigate the biology of a novel target and support small-molecule drug discovery efforts. This is a strong opportunity to play a key role in early-stage scientific discovery within oncology. Title and level will be determined based on experience.

Key Responsibilities

• Design, execute, and troubleshoot in vitro experiments to evaluate target biology, pathway activity, and drug mechanism of action
• Conduct cell-based assays incorporating gene knockdown/knockout (siRNA, shRNA, CRISPR), overexpression systems, and pharmacologic modulation
• Utilize a range of molecular and cellular biology techniques to study signaling pathways, protein trafficking, immune-related responses, and genetic interactions
• Analyze and interpret experimental data with a focus on accuracy, reproducibility, and mechanistic understanding
• Collaborate closely with project teams to ensure experimental strategies align with broader research and therapeutic goals
• Present data and insights effectively in team settings and contribute to ongoing program direction and planning

Qualifications

• PhD in cancer biology, molecular biology, cell biology, or a related scientific discipline
• Postdoctoral training or 4–8 years of industry experience is preferred
• Proven ability to independently design and carry out hypothesis-driven research
• Strong background in mammalian cell culture, viability/proliferation assays, and flow cytometry
• Hands-on experience with techniques such as qRT-PCR, RNA isolation, Western blotting, ELISA, HTRF, MSD, and confocal microscopy
• Experience with functional genomics approaches and assay development for studying protein function, degradation, trafficking, or immune signaling is highly valued
• Strong analytical skills with the ability to integrate data from multiple experimental platforms
• Familiarity with data analysis and visualization tools is a plus
• Experience working with external partners or CROs is beneficial

Ideal Profile

• Demonstrates scientific curiosity paired with a results-oriented mindset
• Thrives in a fast-paced, early-stage research environment
• Adaptable and comfortable navigating evolving scientific challenges
• Effective communicator who collaborates well across teams and contributes to a positive, accountable, and high-performance culture